Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 736615..737143 Replicon chromosome
Accession NZ_CP094254
Organism Acinetobacter indicus strain BDT2076

Toxin (Protein)


Gene name relE Uniprot ID N9N871
Locus tag MOW12_RS03505 Protein ID WP_000221358.1
Coordinates 736615..736908 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID N9NWT9
Locus tag MOW12_RS03510 Protein ID WP_000246755.1
Coordinates 736898..737143 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOW12_RS03485 (MOW12_03485) 731661..732605 - 945 WP_242911932.1 tRNA-dihydrouridine synthase -
MOW12_RS03490 (MOW12_03490) 732762..734087 - 1326 WP_242911933.1 ISNCY family transposase -
MOW12_RS03495 (MOW12_03495) 734337..735110 - 774 WP_163172773.1 glucose 1-dehydrogenase -
MOW12_RS03500 (MOW12_03500) 735208..736413 - 1206 WP_171457096.1 alpha/beta fold hydrolase -
MOW12_RS03505 (MOW12_03505) 736615..736908 - 294 WP_000221358.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MOW12_RS03510 (MOW12_03510) 736898..737143 - 246 WP_000246755.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MOW12_RS03515 (MOW12_03515) 737302..737625 + 324 Protein_669 hypothetical protein -
MOW12_RS03520 (MOW12_03520) 737698..738773 + 1076 WP_152342372.1 IS3 family transposase -
MOW12_RS03525 (MOW12_03525) 738813..739025 - 213 Protein_671 transposase -
MOW12_RS03530 (MOW12_03530) 739375..739794 + 420 WP_039255596.1 PPC domain-containing protein -
MOW12_RS03535 (MOW12_03535) 740150..740503 + 354 Protein_673 integrase core domain-containing protein -
MOW12_RS03540 (MOW12_03540) 740543..741097 + 555 WP_127798694.1 hypothetical protein -
MOW12_RS03545 (MOW12_03545) 741293..742102 - 810 WP_016659852.1 cytochrome c biogenesis protein CcsA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 732762..740503 7741


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11292.52 Da        Isoelectric Point: 10.4753

>T239386 WP_000221358.1 NZ_CP094254:c736908-736615 [Acinetobacter indicus]
MTYKLLRHKDFTAEWEKLPVAIRDQFKKKLAKVIEQPHIPKNMLRGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD

Download         Length: 294 bp

>T239386 NZ_LR890694:c76263-76105 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9249.64 Da        Isoelectric Point: 4.3142

>AT239386 WP_000246755.1 NZ_CP094254:c737143-736898 [Acinetobacter indicus]
MATVNFRIDEALKEKSYSILKEQGIAPTDFFTSILEYVATTGKLPVKKALLSEEDEELLALVRKRINDPKEMFEEVTLDD
L

Download         Length: 246 bp

>AT239386 NZ_LR890694:c76531-76307 [Escherichia coli]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6A1RKP4

Antitoxin

Source ID Structure
AlphaFold DB A0A6A1RJ80

References