Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 126990..127518 Replicon chromosome
Accession NZ_CP094254
Organism Acinetobacter indicus strain BDT2076

Toxin (Protein)


Gene name relE Uniprot ID N9N871
Locus tag MOW12_RS00575 Protein ID WP_000221358.1
Coordinates 126990..127283 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MOW12_RS00580 Protein ID WP_127801964.1
Coordinates 127273..127518 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOW12_RS00540 (MOW12_00540) 122682..122786 - 105 Protein_102 transposase domain-containing protein -
MOW12_RS00545 (MOW12_00545) 122866..123189 + 324 WP_104505828.1 transcriptional regulator -
MOW12_RS00550 (MOW12_00550) 123170..123484 + 315 WP_104505827.1 helix-turn-helix domain-containing protein -
MOW12_RS00555 (MOW12_00555) 123523..123837 + 315 WP_104505826.1 hypothetical protein -
MOW12_RS00560 (MOW12_00560) 124300..125271 - 972 WP_004733159.1 helix-turn-helix domain-containing protein -
MOW12_RS00565 (MOW12_00565) 125404..126288 + 885 WP_005176778.1 MBL fold metallo-hydrolase -
MOW12_RS00570 (MOW12_00570) 126373..126915 + 543 WP_058951821.1 cysteine hydrolase family protein -
MOW12_RS00575 (MOW12_00575) 126990..127283 - 294 WP_000221358.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MOW12_RS00580 (MOW12_00580) 127273..127518 - 246 WP_127801964.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MOW12_RS00585 (MOW12_00585) 127628..128953 - 1326 WP_163169897.1 ISNCY family transposase -
MOW12_RS00590 (MOW12_00590) 129196..129792 + 597 WP_074163998.1 LysE family transporter -
MOW12_RS00595 (MOW12_00595) 129820..130638 - 819 WP_127801903.1 AraC family transcriptional regulator -
MOW12_RS00600 (MOW12_00600) 130880..131467 + 588 Protein_114 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage dfrA16 / blaCARB-2 / aadA2 / cmlA1 / ant(3'')-Ia / qacE / sul1 - 105773..170259 64486


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-71)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11292.52 Da        Isoelectric Point: 10.4753

>T239385 WP_000221358.1 NZ_CP094254:c127283-126990 [Acinetobacter indicus]
MTYKLLRHKDFTAEWEKLPVAIRDQFKKKLAKVIEQPHIPKNMLRGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD

Download         Length: 294 bp

>T239385 NZ_LR890694:c34936-34787 [Escherichia coli]
ATGACGAAGTATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9279.66 Da        Isoelectric Point: 4.3142

>AT239385 WP_127801964.1 NZ_CP094254:c127518-127273 [Acinetobacter indicus]
MATVNFRIDETLKEKSYSILKEQGIAPTDFFTSILEYVATTGKLPVKKALLSEEDEELLALVRKRINDPKEMFEEVTLDD
L

Download         Length: 246 bp

>AT239385 NZ_LR890694:34981-35040 [Escherichia coli]
AATGTACTTCATGCAGACCTCACGAGTTAATGGATTAACAAGTGGGGTCTTTGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6A1RKP4

Antitoxin

Source ID Structure

References