Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/HTH_IclR(antitoxin) |
| Location | 5268608..5270298 | Replicon | chromosome |
| Accession | NZ_CP094240 | ||
| Organism | Comamonas sp. 7D-2evo2 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | A0A5D9AYH5 |
| Locus tag | MP579_RS24260 | Protein ID | WP_034350832.1 |
| Coordinates | 5269420..5270298 (-) | Length | 293 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | A0A096DUZ8 |
| Locus tag | MP579_RS24255 | Protein ID | WP_034351506.1 |
| Coordinates | 5268608..5269414 (-) | Length | 269 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MP579_RS24230 (MP579_24230) | 5263716..5264573 | - | 858 | WP_034350821.1 | IclR family transcriptional regulator | - |
| MP579_RS24235 (MP579_24235) | 5264581..5265357 | - | 777 | WP_034350824.1 | SDR family oxidoreductase | - |
| MP579_RS24240 (MP579_24240) | 5265682..5266440 | - | 759 | WP_034350827.1 | 5'-methylthioadenosine/adenosylhomocysteine nucleosidase | - |
| MP579_RS24245 (MP579_24245) | 5266560..5267558 | - | 999 | WP_034350829.1 | tripartite tricarboxylate transporter substrate binding protein | - |
| MP579_RS24250 (MP579_24250) | 5267765..5268565 | - | 801 | WP_034350831.1 | aspartate dehydrogenase | - |
| MP579_RS24255 (MP579_24255) | 5268608..5269414 | - | 807 | WP_034351506.1 | IclR family transcriptional regulator | Antitoxin |
| MP579_RS24260 (MP579_24260) | 5269420..5270298 | - | 879 | WP_034350832.1 | alpha/beta hydrolase | Toxin |
| MP579_RS24265 (MP579_24265) | 5270307..5270840 | - | 534 | WP_003072476.1 | cupin domain-containing protein | - |
| MP579_RS24270 (MP579_24270) | 5271102..5272778 | - | 1677 | WP_034350834.1 | long-chain-fatty-acid--CoA ligase | - |
| MP579_RS24275 (MP579_24275) | 5272992..5274056 | - | 1065 | WP_004340312.1 | fructose-bisphosphate aldolase class II | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 293 a.a. Molecular weight: 30737.26 Da Isoelectric Point: 5.8809
>T239384 WP_034350832.1 NZ_CP094240:c5270298-5269420 [Comamonas sp. 7D-2evo2]
MHEDLLSLKLQLLQTGFPERLVKLPQGAQVAWREAGDASSDFAVVLLHGISSGAASWLDVALQLADKVRVLAWDAPGYGV
STPLAQSAPADADYAQALAQSLLVLGVRRCILVGHSLGALMAARLAAMAAPGLVEQLVLISPAGGYGAEAKAEQQAKVRE
GRLAALAEKGVAGLAAVIDQRLVSSEAPEVVRAWVRWNTARMQPQGYAQAVELLCGSDLAQARGRLDMPVEVWVGEHDVV
TTPAACKSWSEMLGAHYGTLAAAGHASPVEQPMEVAHRLASLLNQSYCPNTS
MHEDLLSLKLQLLQTGFPERLVKLPQGAQVAWREAGDASSDFAVVLLHGISSGAASWLDVALQLADKVRVLAWDAPGYGV
STPLAQSAPADADYAQALAQSLLVLGVRRCILVGHSLGALMAARLAAMAAPGLVEQLVLISPAGGYGAEAKAEQQAKVRE
GRLAALAEKGVAGLAAVIDQRLVSSEAPEVVRAWVRWNTARMQPQGYAQAVELLCGSDLAQARGRLDMPVEVWVGEHDVV
TTPAACKSWSEMLGAHYGTLAAAGHASPVEQPMEVAHRLASLLNQSYCPNTS
Download Length: 879 bp
>T239384 NZ_LR890693:4638189-4638491 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA
Antitoxin
Download Length: 269 a.a. Molecular weight: 29217.14 Da Isoelectric Point: 5.1557
>AT239384 WP_034351506.1 NZ_CP094240:c5269414-5268608 [Comamonas sp. 7D-2evo2]
MSETSEISTNEQDRYTVPALDRGLRLLACFGPAQPVWSAPELARSLELPRSTVFRMLTTLENSGYLQRSGTEYRLGLAVL
RLGYDYLSTQPLAQLAEPVLQALCDELGMTSNLALRDGTSVVYVARVTPSGAFQGAVRVGSRLPAHATVLGRALLHDMDG
AQLRSVFGGEELPQFSESTPRNVDELLRLLAEDRERGYAMGEGFYEPGVSSIAAPVRAADGQVVAGLAMAIPFTELGPEK
TQLWVQKVQQAAETLSAHLRQQHPDHLR
MSETSEISTNEQDRYTVPALDRGLRLLACFGPAQPVWSAPELARSLELPRSTVFRMLTTLENSGYLQRSGTEYRLGLAVL
RLGYDYLSTQPLAQLAEPVLQALCDELGMTSNLALRDGTSVVYVARVTPSGAFQGAVRVGSRLPAHATVLGRALLHDMDG
AQLRSVFGGEELPQFSESTPRNVDELLRLLAEDRERGYAMGEGFYEPGVSSIAAPVRAADGQVVAGLAMAIPFTELGPEK
TQLWVQKVQQAAETLSAHLRQQHPDHLR
Download Length: 807 bp
>AT239384 NZ_LR890693:4638527-4638868 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5D9AYH5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A096DUZ8 |