Detailed information of TA system TA239383

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3934381..3935051
• Replicon: chromosome
• Accession: NZ_CP094240
• Organism: Comamonas sp. 7D-2evo2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: MP579_RS18150
• Protein ID: WP_242881849.1
• Coordinates: 3934381..3934557 (+)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: MP579_RS18155
• Protein ID: WP_242881850.1
• Coordinates: 3934623..3935051 (+)
• Length: 143 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3924500..3987770	63270

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-73)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6737.70 Da
• Isoelectric Point: 11.0738

>T239383 WP_242881849.1 NZ_CP094240:3934381-3934557 [Comamonas sp. 7D-2evo2]
VKISEFKRWLEAQGVKVENGTNHWRLYHNGNTSTLPRHPSKELKEGTRRAILKQLGIN

Nucleotide

• Length: 177 bp

>T239383 NZ_LR890693:c4609235-4609017 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 143 a.a.
• Molecular weight: 15238.48 Da
• Isoelectric Point: 4.8066

>AT239383 WP_242881850.1 NZ_CP094240:3934623-3935051 [Comamonas sp. 7D-2evo2]
MQKYPARFDPADEGGYTVTFRDIPEAITQGDDLAEAESMARDALVTAMEFYFEAGRAVPAPSKAEKGERLVELPASVAVK
VALLNARLATGARPADVARAMGVKPQEMTRVFDLGHATKIDTVAAALAAMGYELELTVRPIK

Nucleotide

• Length: 429 bp

>AT239383 NZ_LR890693:c4609635-4609261 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG