Detailed information of TA system TA239383

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3934381..3935051
• Replicon: chromosome
• Accession: NZ_CP094240
• Organism: Comamonas sp. 7D-2evo2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: MP579_RS18150
• Protein ID: WP_242881849.1
• Coordinates: 3934381..3934557 (+)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: MP579_RS18155
• Protein ID: WP_242881850.1
• Coordinates: 3934623..3935051 (+)
• Length: 143 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MP579_RS18120 (MP579_18120)	3930297..3931110	+	814	Protein_3543	IS5 family transposase	-
MP579_RS18130 (MP579_18130)	3931504..3931920	+	417	WP_242881844.1	translesion error-prone DNA polymerase V autoproteolytic subunit	-
MP579_RS18135 (MP579_18135)	3931925..3932782	+	858	WP_242881846.1	excinuclease Cho	-
MP579_RS18140 (MP579_18140)	3932792..3934090	+	1299	WP_242881847.1	Y-family DNA polymerase	-
MP579_RS18145 (MP579_18145)	3934090..3934302	+	213	WP_242881848.1	hypothetical protein	-
MP579_RS18150 (MP579_18150)	3934381..3934557	+	177	WP_242881849.1	type II toxin-antitoxin system HicA family toxin	Toxin
MP579_RS18155 (MP579_18155)	3934623..3935051	+	429	WP_242881850.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
MP579_RS18160 (MP579_18160)	3935064..3935558	-	495	WP_242881851.1	hypothetical protein	-
MP579_RS18165 (MP579_18165)	3935555..3936025	-	471	WP_242881852.1	lysozyme	-
MP579_RS18170 (MP579_18170)	3936022..3936339	-	318	WP_242881853.1	hypothetical protein	-
MP579_RS18175 (MP579_18175)	3936371..3936607	-	237	WP_242881854.1	hypothetical protein	-
MP579_RS18180 (MP579_18180)	3936604..3938499	-	1896	WP_242881855.1	hypothetical protein	-
MP579_RS18185 (MP579_18185)	3938499..3938894	-	396	WP_242881856.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3924500..3987770	63270

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-73)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6737.70 Da
• Isoelectric Point: 11.0738

>T239383 WP_242881849.1 NZ_CP094240:3934381-3934557 [Comamonas sp. 7D-2evo2]
VKISEFKRWLEAQGVKVENGTNHWRLYHNGNTSTLPRHPSKELKEGTRRAILKQLGIN

Nucleotide

• Length: 177 bp

>T239383 NZ_LR890693:c4609235-4609017 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 143 a.a.
• Molecular weight: 15238.48 Da
• Isoelectric Point: 4.8066

>AT239383 WP_242881850.1 NZ_CP094240:3934623-3935051 [Comamonas sp. 7D-2evo2]
MQKYPARFDPADEGGYTVTFRDIPEAITQGDDLAEAESMARDALVTAMEFYFEAGRAVPAPSKAEKGERLVELPASVAVK
VALLNARLATGARPADVARAMGVKPQEMTRVFDLGHATKIDTVAAALAAMGYELELTVRPIK

Nucleotide

• Length: 429 bp

>AT239383 NZ_LR890693:c4609635-4609261 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG