Detailed information of TA system TA239382

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 3772560..3773238
• Replicon: chromosome
• Accession: NZ_CP094240
• Organism: Comamonas sp. 7D-2evo2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A0L7MPR3
• Locus tag: MP579_RS17375
• Protein ID: WP_053282542.1
• Coordinates: 3772560..3772736 (+)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: MP579_RS17380
• Protein ID: WP_242881762.1
• Coordinates: 3772801..3773238 (+)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MP579_RS17355 (MP579_17355)	3768775..3770427	+	1653	WP_242881756.1	recombinase family protein	-
MP579_RS17360 (MP579_17360)	3770544..3770957	+	414	WP_242881758.1	translesion error-prone DNA polymerase V autoproteolytic subunit	-
MP579_RS17365 (MP579_17365)	3770964..3772262	+	1299	WP_242881760.1	Y-family DNA polymerase	-
MP579_RS17370 (MP579_17370)	3772262..3772474	+	213	WP_242881761.1	hypothetical protein	-
MP579_RS17375 (MP579_17375)	3772560..3772736	+	177	WP_053282542.1	type II toxin-antitoxin system HicA family toxin	Toxin
MP579_RS17380 (MP579_17380)	3772801..3773238	+	438	WP_242881762.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
MP579_RS17385 (MP579_17385)	3773219..3773713	-	495	WP_242881763.1	hypothetical protein	-
MP579_RS17390 (MP579_17390)	3773710..3774180	-	471	WP_045839658.1	lysozyme	-
MP579_RS17395 (MP579_17395)	3774177..3774494	-	318	WP_242881764.1	hypothetical protein	-
MP579_RS17400 (MP579_17400)	3774505..3774795	-	291	WP_242881765.1	hypothetical protein	-
MP579_RS17405 (MP579_17405)	3774798..3775193	-	396	WP_242881767.1	hypothetical protein	-
MP579_RS17410 (MP579_17410)	3775364..3776602	-	1239	WP_242881769.1	hypothetical protein	-
MP579_RS17415 (MP579_17415)	3776599..3777354	-	756	WP_242881771.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3759881..3821135	61254

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-63)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6599.73 Da
• Isoelectric Point: 11.7505

>T239382 WP_053282542.1 NZ_CP094240:3772560-3772736 [Comamonas sp. 7D-2evo2]
MKQSEFQRWLAAQGATFSHGTRHLKVFLNGKQTIMPRHPSQEIGEGLRKAILKQLGLK

Nucleotide

• Length: 177 bp

>T239382 NZ_LR890693:4423855-4424775 [Escherichia coli]
ATGGATCTGCGTGATAGCTATGCCAGGCAGGTTAAACTGTTGATGGCCGCTCTGCCGCATGTGGCGAAGGAATCCTGTTT
CGCGTTGAAAGGCGGCACAGCAATCAATTTATTTGTGCAGGATTTCCCCCGTCTATCGGTGGATATCGATCTGGCGTATA
AGAGCTTTGCGGATCGCGATACCGATCTGGCGGCGATCAACGACGCTTTGAAGAGAATTACTGCATCGCTGAACGGCAGA
CCGGGGATCACCGCGATTCGGCAGGAAAATAAAGCGGATGAAAAGCGCATCATTGTGAATACCGCTGATGCAAAGATTAA
GATCGAGGTTAGCCCGGTCTGGCGCGGGCTGTTGTTGCCTCCGGCAGAAATGCCTGTGTGCGAACGTGTGGAAATGGAGT
ATGGCTTCACCACCATGAGTGTCGTCTCGCTGGCGGATCTTTATGGCGGTAAAATATGTGCTGCGCTTGATCGTCAGCAT
CCGCGCGATCTGTTTGATGTGTTGAATATGCTGGGGAGACCGGGCCTGACGCGCGAAATTTTTGACGGTTTTCTTTGTTA
TCTGGCAGGCCATCCCCGTCCCATTGCCGAGTTGCTGGCTTCAAACTGGGATACAGATCGGATTGCCACGTTATACGCTC
AGGAATTTTCGGGGATGACTCAGCAGGAAACGTCGCTGGAATCGCTTCTGTCAGTAACGACTTTGCTGCCGCAGGCGTTG
AAGTCACATTTTACGGATCTGGATCGCGAGTTCTTGCTCAGTTTTAAGCAAAACAGCCCTGACTGGTCGCGGTATCGCTA
TCCTGAAATTCAGCATCTTCCGGCTATTCGCTGGAAGCAACGCAATCTGGCGATGCTTAAAGATAAAAATCCGGCGAAGT
ATGTGGCGGCGGTGAATAAGCTAGAGAGGGTGCTGGAGTAA

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 15657.01 Da
• Isoelectric Point: 5.2039

>AT239382 WP_242881762.1 NZ_CP094240:3772801-3773238 [Comamonas sp. 7D-2evo2]
MRFPANIEPDGDGFMVSFPDIPEALTCGDTYDEAVSMAHDALLTAMDFYFDDRRAVPEPSKAAKGQVLISLPASVSAKVL
LLNEMVHQGVRPIDLAARMGTTKQEVNRLTDLKHATKIDTIAKALATMGLDLELGVRRSATAAAR

Nucleotide

• Length: 438 bp

>AT239382 NZ_LR890693:4423086-4423868 [Escherichia coli]
TTGCCAAACTATCTAAACTGGTTGATGCAAAACACGCTACCCGGTCAGGTGCTGCTCCAGTCATGGCTTACCCGCAATGG
CGTAGATCGTAAGCTTTCTTATCTCTATGTTCAGAATGGCTGGCTCAGGCGCATCGCTCACGGTGTGTACTGCCGGACGG
GCCGTGAGCCGGATTGGGTAGACGCGGTTTACTGCCTTCAAACACAGTGGGAAAAGCCTGTTCGGGTGGCGGGGCTAACC
AGCCTTGCGCTTCAGGGCCATGCGCACTATACCGAACCGGGTAAGCCGCAGGTCTGGCTCGCGCTTCCGGCTTACGTCAA
ACTGCCGGGATGGTTTGCTGCCTTCGAACAATCAGCAACATTTATCACGCTGTATACATCGGGCCTTACCGTTGATGTCT
CGTCATTTACTACGGAACTGAAAATTGGCGACCGGCAGTTAGCAGGCAGTGCACCGGAACTGGCCGCGTATGAGATCGCC
TGCGGCGTTCCTTCGTTGATCTCGTTCGAACATGCCGATGCTCTGTTTCAGGGGGGGAATCTTCTCAGCCCACGCAAATT
GCAGGCACTGCTTCGCGCCAGTCATTCGATTAAAACCAACCGGGTGATGCTTTACCTTGCCCGGCGTAATGGACACCCTT
ATTTTCAGTATCTTGATCAAAGCGGTATAGAAACAGGTACGGGAAAGCGGCAAATCATACCTGGTGGCTGGCTGGAGCCG
GATTATCAAATTACTGTTCCCCGCACATTTAAACCGGAAGGAGTCGAAGATGGATCTGCGTGA

Structures

Toxin

• AlphaFold DB: A0A0L7MPR3