Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 3078300..3079869 Replicon chromosome
Accession NZ_CP094240
Organism Comamonas sp. 7D-2evo2

Toxin (Protein)


Gene name HipA1 Uniprot ID A0A5D9ALV0
Locus tag MP579_RS14250 Protein ID WP_034355871.1
Coordinates 3078300..3079598 (-) Length 433 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID A0A5D9ANP1
Locus tag MP579_RS14255 Protein ID WP_034355868.1
Coordinates 3079588..3079869 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MP579_RS14235 (MP579_14235) 3074966..3075322 + 357 WP_034355880.1 zinc ribbon domain-containing protein YjdM -
MP579_RS14240 (MP579_14240) 3076085..3077455 + 1371 WP_034355877.1 MFS transporter -
MP579_RS14245 (MP579_14245) 3077588..3078064 - 477 WP_080746107.1 GFA family protein -
MP579_RS14250 (MP579_14250) 3078300..3079598 - 1299 WP_034355871.1 type II toxin-antitoxin system HipA family toxin Toxin
MP579_RS14255 (MP579_14255) 3079588..3079869 - 282 WP_034355868.1 helix-turn-helix transcriptional regulator Antitoxin
MP579_RS14260 (MP579_14260) 3079883..3080050 + 168 WP_165571706.1 hypothetical protein -
MP579_RS14265 (MP579_14265) 3080193..3082031 - 1839 WP_034355865.1 dihydrolipoyl dehydrogenase -
MP579_RS14280 (MP579_14280) 3082124..3082999 - 876 WP_034355862.1 hypothetical protein -
MP579_RS14285 (MP579_14285) 3083115..3084797 - 1683 WP_034355859.1 dihydrolipoyllysine-residue acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2645726..3210757 565031


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-60)


Sequences

Toxin        


Download         Length: 433 a.a.        Molecular weight: 46957.96 Da        Isoelectric Point: 7.2604

>T239381 WP_034355871.1 NZ_CP094240:c3079598-3078300 [Comamonas sp. 7D-2evo2]
MTHELEVWLFERRVGSLSLVHGRLSFAYATEWLALPQATALSQSLPLQAEPFGDHQTRPFFAGLLPEGQMRRLIAQQFQV
SGQNDFALLDHIGGECAGAVTFLEPGQALPQTDGAGATRESGDVEWLSDQKLLALLDELPRRPMLAGDDGLRLSLAGAQD
KLPVVVDDSIPGAVRIGLPRNGAPSSHILKPAIHAVEDSVANEGFCMLLAQVMGLRPANARIQSVLGRSFLLVKRYDRVL
KDDAQGQAQLQRLHQEDFCQALGVVPELKYQNEGGPGLAQCFALARSVTRPSAPQVLRLLDGVIFNALIGNHDAHGKNFS
LLYGGRAPVLAPFYDLLATAIYPQLTPKMAMKIGSKYKFSELEARHWEQFAEEAGLAKAATSKRLQQLANELPAAARKLQ
AAPPHGFAGNAVVTQIVQLIEQRCALTLRRLA

Download         Length: 1299 bp

>T239381 NZ_LR890693:4156887-4157171 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGATAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAATGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 9560.77 Da        Isoelectric Point: 5.0093

>AT239381 WP_034355868.1 NZ_CP094240:c3079869-3079588 [Comamonas sp. 7D-2evo2]
MSTIHTTDQLGTALRIARKQLGLTQPQLALAAGVGTRFIVDLESGKPTVRLEHVLRVIDALGGELQLGGLPEAAHEDGAG
QAAAATEGADHDA

Download         Length: 282 bp

>AT239381 NZ_LR890693:4156651-4156884 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5D9ALV0

Antitoxin

Source ID Structure
AlphaFold DB A0A5D9ANP1

References