Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/HTH_IclR(antitoxin) |
| Location | 5278030..5279720 | Replicon | chromosome |
| Accession | NZ_CP094239 | ||
| Organism | Comamonas sp. 7D-2evo1 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | A0A5D9AYH5 |
| Locus tag | MP576_RS24330 | Protein ID | WP_034350832.1 |
| Coordinates | 5278842..5279720 (-) | Length | 293 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | A0A096DUZ8 |
| Locus tag | MP576_RS24325 | Protein ID | WP_034351506.1 |
| Coordinates | 5278030..5278836 (-) | Length | 269 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MP576_RS24300 (MP576_24300) | 5273138..5273995 | - | 858 | WP_034350821.1 | IclR family transcriptional regulator | - |
| MP576_RS24305 (MP576_24305) | 5274003..5274779 | - | 777 | WP_034350824.1 | SDR family oxidoreductase | - |
| MP576_RS24310 (MP576_24310) | 5275104..5275862 | - | 759 | WP_034350827.1 | 5'-methylthioadenosine/adenosylhomocysteine nucleosidase | - |
| MP576_RS24315 (MP576_24315) | 5275982..5276980 | - | 999 | WP_034350829.1 | tripartite tricarboxylate transporter substrate binding protein | - |
| MP576_RS24320 (MP576_24320) | 5277187..5277987 | - | 801 | WP_034350831.1 | aspartate dehydrogenase | - |
| MP576_RS24325 (MP576_24325) | 5278030..5278836 | - | 807 | WP_034351506.1 | IclR family transcriptional regulator | Antitoxin |
| MP576_RS24330 (MP576_24330) | 5278842..5279720 | - | 879 | WP_034350832.1 | alpha/beta hydrolase | Toxin |
| MP576_RS24335 (MP576_24335) | 5279729..5280262 | - | 534 | WP_003072476.1 | cupin domain-containing protein | - |
| MP576_RS24340 (MP576_24340) | 5280524..5282200 | - | 1677 | WP_034350834.1 | long-chain-fatty-acid--CoA ligase | - |
| MP576_RS24345 (MP576_24345) | 5282414..5283478 | - | 1065 | WP_004340312.1 | fructose-bisphosphate aldolase class II | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 293 a.a. Molecular weight: 30737.26 Da Isoelectric Point: 5.8809
>T239378 WP_034350832.1 NZ_CP094239:c5279720-5278842 [Comamonas sp. 7D-2evo1]
MHEDLLSLKLQLLQTGFPERLVKLPQGAQVAWREAGDASSDFAVVLLHGISSGAASWLDVALQLADKVRVLAWDAPGYGV
STPLAQSAPADADYAQALAQSLLVLGVRRCILVGHSLGALMAARLAAMAAPGLVEQLVLISPAGGYGAEAKAEQQAKVRE
GRLAALAEKGVAGLAAVIDQRLVSSEAPEVVRAWVRWNTARMQPQGYAQAVELLCGSDLAQARGRLDMPVEVWVGEHDVV
TTPAACKSWSEMLGAHYGTLAAAGHASPVEQPMEVAHRLASLLNQSYCPNTS
MHEDLLSLKLQLLQTGFPERLVKLPQGAQVAWREAGDASSDFAVVLLHGISSGAASWLDVALQLADKVRVLAWDAPGYGV
STPLAQSAPADADYAQALAQSLLVLGVRRCILVGHSLGALMAARLAAMAAPGLVEQLVLISPAGGYGAEAKAEQQAKVRE
GRLAALAEKGVAGLAAVIDQRLVSSEAPEVVRAWVRWNTARMQPQGYAQAVELLCGSDLAQARGRLDMPVEVWVGEHDVV
TTPAACKSWSEMLGAHYGTLAAAGHASPVEQPMEVAHRLASLLNQSYCPNTS
Download Length: 879 bp
>T239378 NZ_LR890693:3964749-3965126 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCAGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCAGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA
Antitoxin
Download Length: 269 a.a. Molecular weight: 29217.14 Da Isoelectric Point: 5.1557
>AT239378 WP_034351506.1 NZ_CP094239:c5278836-5278030 [Comamonas sp. 7D-2evo1]
MSETSEISTNEQDRYTVPALDRGLRLLACFGPAQPVWSAPELARSLELPRSTVFRMLTTLENSGYLQRSGTEYRLGLAVL
RLGYDYLSTQPLAQLAEPVLQALCDELGMTSNLALRDGTSVVYVARVTPSGAFQGAVRVGSRLPAHATVLGRALLHDMDG
AQLRSVFGGEELPQFSESTPRNVDELLRLLAEDRERGYAMGEGFYEPGVSSIAAPVRAADGQVVAGLAMAIPFTELGPEK
TQLWVQKVQQAAETLSAHLRQQHPDHLR
MSETSEISTNEQDRYTVPALDRGLRLLACFGPAQPVWSAPELARSLELPRSTVFRMLTTLENSGYLQRSGTEYRLGLAVL
RLGYDYLSTQPLAQLAEPVLQALCDELGMTSNLALRDGTSVVYVARVTPSGAFQGAVRVGSRLPAHATVLGRALLHDMDG
AQLRSVFGGEELPQFSESTPRNVDELLRLLAEDRERGYAMGEGFYEPGVSSIAAPVRAADGQVVAGLAMAIPFTELGPEK
TQLWVQKVQQAAETLSAHLRQQHPDHLR
Download Length: 807 bp
>AT239378 NZ_LR890693:3964291-3964659 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5D9AYH5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A096DUZ8 |