Detailed information of TA system TA239376

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 3770052..3770730
• Replicon: chromosome
• Accession: NZ_CP094239
• Organism: Comamonas sp. 7D-2evo1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A0L7MPR3
• Locus tag: MP576_RS17370
• Protein ID: WP_053282542.1
• Coordinates: 3770052..3770228 (+)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: MP576_RS17375
• Protein ID: WP_242881762.1
• Coordinates: 3770293..3770730 (+)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MP576_RS17350 (MP576_17350)	3766267..3767919	+	1653	WP_242881756.1	recombinase family protein	-
MP576_RS17355 (MP576_17355)	3768036..3768449	+	414	WP_242881758.1	translesion error-prone DNA polymerase V autoproteolytic subunit	-
MP576_RS17360 (MP576_17360)	3768456..3769754	+	1299	WP_242881760.1	Y-family DNA polymerase	-
MP576_RS17365 (MP576_17365)	3769754..3769966	+	213	WP_242881761.1	hypothetical protein	-
MP576_RS17370 (MP576_17370)	3770052..3770228	+	177	WP_053282542.1	type II toxin-antitoxin system HicA family toxin	Toxin
MP576_RS17375 (MP576_17375)	3770293..3770730	+	438	WP_242881762.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
MP576_RS17380 (MP576_17380)	3770711..3771205	-	495	WP_242881763.1	hypothetical protein	-
MP576_RS17385 (MP576_17385)	3771202..3771672	-	471	WP_045839658.1	lysozyme	-
MP576_RS17390 (MP576_17390)	3771669..3771986	-	318	WP_242881764.1	hypothetical protein	-
MP576_RS17395 (MP576_17395)	3771997..3772287	-	291	WP_242881765.1	hypothetical protein	-
MP576_RS17400 (MP576_17400)	3772290..3772685	-	396	WP_242881767.1	hypothetical protein	-
MP576_RS17405 (MP576_17405)	3772856..3774094	-	1239	WP_242881769.1	hypothetical protein	-
MP576_RS17410 (MP576_17410)	3774091..3774846	-	756	WP_242881771.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3757373..3818627	61254

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-63)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6599.73 Da
• Isoelectric Point: 11.7505

>T239376 WP_053282542.1 NZ_CP094239:3770052-3770228 [Comamonas sp. 7D-2evo1]
MKQSEFQRWLAAQGATFSHGTRHLKVFLNGKQTIMPRHPSQEIGEGLRKAILKQLGLK

Nucleotide

• Length: 177 bp

>T239376 NZ_LR890693:3764795-3764968 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTTTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 15657.01 Da
• Isoelectric Point: 5.2039

>AT239376 WP_242881762.1 NZ_CP094239:3770293-3770730 [Comamonas sp. 7D-2evo1]
MRFPANIEPDGDGFMVSFPDIPEALTCGDTYDEAVSMAHDALLTAMDFYFDDRRAVPEPSKAAKGQVLISLPASVSAKVL
LLNEMVHQGVRPIDLAARMGTTKQEVNRLTDLKHATKIDTIAKALATMGLDLELGVRRSATAAAR

Nucleotide

• Length: 438 bp

>AT239376 NZ_LR890693:3764471-3764767 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Toxin

• AlphaFold DB: A0A0L7MPR3