Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 3084420..3085989 Replicon chromosome
Accession NZ_CP094239
Organism Comamonas sp. 7D-2evo1

Toxin (Protein)


Gene name HipA1 Uniprot ID A0A5D9ALV0
Locus tag MP576_RS14295 Protein ID WP_034355871.1
Coordinates 3084420..3085718 (-) Length 433 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID A0A5D9ANP1
Locus tag MP576_RS14300 Protein ID WP_034355868.1
Coordinates 3085708..3085989 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MP576_RS14280 (MP576_14280) 3081086..3081442 + 357 WP_034355880.1 zinc ribbon domain-containing protein YjdM -
MP576_RS14285 (MP576_14285) 3082205..3083575 + 1371 WP_034355877.1 MFS transporter -
MP576_RS14290 (MP576_14290) 3083708..3084184 - 477 WP_080746107.1 GFA family protein -
MP576_RS14295 (MP576_14295) 3084420..3085718 - 1299 WP_034355871.1 type II toxin-antitoxin system HipA family toxin Toxin
MP576_RS14300 (MP576_14300) 3085708..3085989 - 282 WP_034355868.1 helix-turn-helix transcriptional regulator Antitoxin
MP576_RS14305 (MP576_14305) 3086313..3088151 - 1839 WP_034355865.1 dihydrolipoyl dehydrogenase -
MP576_RS14320 (MP576_14320) 3088244..3089119 - 876 WP_034355862.1 hypothetical protein -
MP576_RS14325 (MP576_14325) 3089235..3090917 - 1683 WP_034355859.1 dihydrolipoyllysine-residue acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2623045..3191140 568095


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-60)


Sequences

Toxin        


Download         Length: 433 a.a.        Molecular weight: 46957.96 Da        Isoelectric Point: 7.2604

>T239375 WP_034355871.1 NZ_CP094239:c3085718-3084420 [Comamonas sp. 7D-2evo1]
MTHELEVWLFERRVGSLSLVHGRLSFAYATEWLALPQATALSQSLPLQAEPFGDHQTRPFFAGLLPEGQMRRLIAQQFQV
SGQNDFALLDHIGGECAGAVTFLEPGQALPQTDGAGATRESGDVEWLSDQKLLALLDELPRRPMLAGDDGLRLSLAGAQD
KLPVVVDDSIPGAVRIGLPRNGAPSSHILKPAIHAVEDSVANEGFCMLLAQVMGLRPANARIQSVLGRSFLLVKRYDRVL
KDDAQGQAQLQRLHQEDFCQALGVVPELKYQNEGGPGLAQCFALARSVTRPSAPQVLRLLDGVIFNALIGNHDAHGKNFS
LLYGGRAPVLAPFYDLLATAIYPQLTPKMAMKIGSKYKFSELEARHWEQFAEEAGLAKAATSKRLQQLANELPAAARKLQ
AAPPHGFAGNAVVTQIVQLIEQRCALTLRRLA

Download         Length: 1299 bp

>T239375 NZ_LR890693:3436559-3436870 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGAACGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTCTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 9560.77 Da        Isoelectric Point: 5.0093

>AT239375 WP_034355868.1 NZ_CP094239:c3085989-3085708 [Comamonas sp. 7D-2evo1]
MSTIHTTDQLGTALRIARKQLGLTQPQLALAAGVGTRFIVDLESGKPTVRLEHVLRVIDALGGELQLGGLPEAAHEDGAG
QAAAATEGADHDA

Download         Length: 282 bp

>AT239375 NZ_LR890693:3436871-3437161 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5D9ALV0

Antitoxin

Source ID Structure
AlphaFold DB A0A5D9ANP1

References