Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2961066..2961667 Replicon chromosome
Accession NZ_CP094239
Organism Comamonas sp. 7D-2evo1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MP576_RS13725 Protein ID WP_019042333.1
Coordinates 2961281..2961667 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A076PMR1
Locus tag MP576_RS13720 Protein ID WP_034356765.1
Coordinates 2961066..2961281 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MP576_RS13695 (MP576_13695) 2956507..2956953 + 447 WP_019042328.1 Cd(II)/Pb(II)-responsive transcriptional regulator -
MP576_RS13700 (MP576_13700) 2957033..2957422 - 390 WP_080571250.1 CzcE family metal-binding protein -
MP576_RS13705 (MP576_13705) 2957674..2959347 + 1674 WP_230629841.1 phosphoethanolamine transferase -
MP576_RS13710 (MP576_13710) 2959684..2960010 - 327 WP_019042331.1 transposase -
MP576_RS13715 (MP576_13715) 2960164..2960981 - 818 Protein_2679 SprT-like domain-containing protein -
MP576_RS13720 (MP576_13720) 2961066..2961281 + 216 WP_034356765.1 DUF2191 domain-containing protein Antitoxin
MP576_RS13725 (MP576_13725) 2961281..2961667 + 387 WP_019042333.1 twitching motility protein PilT Toxin
MP576_RS13730 (MP576_13730) 2961756..2961965 + 210 WP_034356767.1 hypothetical protein -
MP576_RS13735 (MP576_13735) 2962145..2962945 + 801 WP_242881683.1 translesion DNA synthesis-associated protein ImuA -
MP576_RS13740 (MP576_13740) 2962890..2964200 + 1311 WP_034356769.1 DNA polymerase Y family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2623045..3191140 568095


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 13999.29 Da        Isoelectric Point: 5.0594

>T239374 WP_019042333.1 NZ_CP094239:2961281-2961667 [Comamonas sp. 7D-2evo1]
MPVSVLVDTSVWVRHFREADTHLQELLMQDSVLMHSMVHAELACGTPPAPRADTLAALAMLRPSQEASIPETLEFLEQNK
LFGKGCGLVDLSLLASTLITPGALLWTADRRLADMATQLNVAYLPPLH

Download         Length: 387 bp

>T239374 NZ_LR890693:c3040646-3040539 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7519.50 Da        Isoelectric Point: 5.0166

>AT239374 WP_034356765.1 NZ_CP094239:2961066-2961281 [Comamonas sp. 7D-2evo1]
MRSTFTIDDDVVNRARAVAAPGIAVPELVRLALETFTRVEAGKRLAALGGAAPNMPDVPRRGSEADAEDSR

Download         Length: 216 bp

>AT239374 NZ_LR890693:3040695-3040760 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A076PMR1

References