Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2237771..2238366 Replicon chromosome
Accession NZ_CP094239
Organism Comamonas sp. 7D-2evo1

Toxin (Protein)


Gene name relE Uniprot ID A0A5D9AQV8
Locus tag MP576_RS10315 Protein ID WP_034358561.1
Coordinates 2237771..2238067 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MP576_RS10320 Protein ID WP_187771848.1
Coordinates 2238070..2238366 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MP576_RS10295 (MP576_10295) 2232771..2234339 + 1569 WP_034358565.1 sensor domain-containing diguanylate cyclase -
MP576_RS10300 (MP576_10300) 2235026..2235289 - 264 WP_003061434.1 translation initiation factor IF-1 -
MP576_RS10305 (MP576_10305) 2235313..2235531 - 219 WP_003053604.1 hypothetical protein -
MP576_RS10310 (MP576_10310) 2236080..2237420 + 1341 WP_034358562.1 integrase family protein -
MP576_RS10315 (MP576_10315) 2237771..2238067 + 297 WP_034358561.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MP576_RS10320 (MP576_10320) 2238070..2238366 + 297 WP_187771848.1 putative addiction module antidote protein Antitoxin
MP576_RS10325 (MP576_10325) 2238549..2239391 + 843 WP_131324717.1 hypothetical protein -
MP576_RS10330 (MP576_10330) 2239538..2239786 + 249 WP_034358558.1 hypothetical protein -
MP576_RS10335 (MP576_10335) 2239786..2240067 + 282 WP_034358555.1 hypothetical protein -
MP576_RS10340 (MP576_10340) 2240129..2240473 + 345 WP_034358553.1 hypothetical protein -
MP576_RS10345 (MP576_10345) 2240473..2241423 + 951 WP_052057663.1 toprim domain-containing protein -
MP576_RS10350 (MP576_10350) 2241413..2243248 + 1836 WP_080746132.1 DUF927 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2230579..2264865 34286


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Uncharacterized protein HI1420

(9-95)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10954.57 Da        Isoelectric Point: 6.4592

>T239373 WP_034358561.1 NZ_CP094239:2237771-2238067 [Comamonas sp. 7D-2evo1]
MFTIKRTAEFDAWLFGLRDTMTRIRLAKRLDKVQRGPLGDTKPVGDGVHELREDFGPGWCMYYVQHGDVLVVMLGGGDKS
TQQADIQAAIALSKTLED

Download         Length: 297 bp

>T239373 NZ_LR890693:c3040163-3040056 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10576.17 Da        Isoelectric Point: 5.1006

>AT239373 WP_187771848.1 NZ_CP094239:2238070-2238366 [Comamonas sp. 7D-2evo1]
MTKIADLPTFDMAEHLKTDEDLAAYLSLVLEEDDPAELANALGVIARARGMTEIASASGLTREALYKALRPGSQPRFDTI
RRVCGALGVRLVAQPIHA

Download         Length: 297 bp

>AT239373 NZ_LR890693:3040220-3040277 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5D9AQV8

Antitoxin

Source ID Structure

References