Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/HTH_IclR(antitoxin) |
| Location | 5233027..5234717 | Replicon | chromosome |
| Accession | NZ_CP094238 | ||
| Organism | Comamonas sp. 7D-2 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | A0A5D9AYH5 |
| Locus tag | MPZ60_RS24115 | Protein ID | WP_034350832.1 |
| Coordinates | 5233839..5234717 (-) | Length | 293 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | A0A096DUZ8 |
| Locus tag | MPZ60_RS24110 | Protein ID | WP_034351506.1 |
| Coordinates | 5233027..5233833 (-) | Length | 269 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MPZ60_RS24085 (MPZ60_24085) | 5228135..5228992 | - | 858 | WP_034350821.1 | IclR family transcriptional regulator | - |
| MPZ60_RS24090 (MPZ60_24090) | 5229000..5229776 | - | 777 | WP_034350824.1 | SDR family oxidoreductase | - |
| MPZ60_RS24095 (MPZ60_24095) | 5230101..5230859 | - | 759 | WP_034350827.1 | 5'-methylthioadenosine/adenosylhomocysteine nucleosidase | - |
| MPZ60_RS24100 (MPZ60_24100) | 5230979..5231977 | - | 999 | WP_034350829.1 | tripartite tricarboxylate transporter substrate binding protein | - |
| MPZ60_RS24105 (MPZ60_24105) | 5232184..5232984 | - | 801 | WP_034350831.1 | aspartate dehydrogenase | - |
| MPZ60_RS24110 (MPZ60_24110) | 5233027..5233833 | - | 807 | WP_034351506.1 | IclR family transcriptional regulator | Antitoxin |
| MPZ60_RS24115 (MPZ60_24115) | 5233839..5234717 | - | 879 | WP_034350832.1 | alpha/beta hydrolase | Toxin |
| MPZ60_RS24120 (MPZ60_24120) | 5234726..5235259 | - | 534 | WP_003072476.1 | cupin domain-containing protein | - |
| MPZ60_RS24125 (MPZ60_24125) | 5235521..5237197 | - | 1677 | WP_034350834.1 | long-chain-fatty-acid--CoA ligase | - |
| MPZ60_RS24130 (MPZ60_24130) | 5237411..5238475 | - | 1065 | WP_004340312.1 | fructose-bisphosphate aldolase class II | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 293 a.a. Molecular weight: 30737.26 Da Isoelectric Point: 5.8809
>T239372 WP_034350832.1 NZ_CP094238:c5234717-5233839 [Comamonas sp. 7D-2]
MHEDLLSLKLQLLQTGFPERLVKLPQGAQVAWREAGDASSDFAVVLLHGISSGAASWLDVALQLADKVRVLAWDAPGYGV
STPLAQSAPADADYAQALAQSLLVLGVRRCILVGHSLGALMAARLAAMAAPGLVEQLVLISPAGGYGAEAKAEQQAKVRE
GRLAALAEKGVAGLAAVIDQRLVSSEAPEVVRAWVRWNTARMQPQGYAQAVELLCGSDLAQARGRLDMPVEVWVGEHDVV
TTPAACKSWSEMLGAHYGTLAAAGHASPVEQPMEVAHRLASLLNQSYCPNTS
MHEDLLSLKLQLLQTGFPERLVKLPQGAQVAWREAGDASSDFAVVLLHGISSGAASWLDVALQLADKVRVLAWDAPGYGV
STPLAQSAPADADYAQALAQSLLVLGVRRCILVGHSLGALMAARLAAMAAPGLVEQLVLISPAGGYGAEAKAEQQAKVRE
GRLAALAEKGVAGLAAVIDQRLVSSEAPEVVRAWVRWNTARMQPQGYAQAVELLCGSDLAQARGRLDMPVEVWVGEHDVV
TTPAACKSWSEMLGAHYGTLAAAGHASPVEQPMEVAHRLASLLNQSYCPNTS
Download Length: 879 bp
>T239372 NZ_LR890693:c2937665-2937138 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCATT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTCTGCGAGCGTATATCCTGTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTAACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTTGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCATTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCGACCAAATCTATAGAGCTACTTTTTACACCAGACGATTAA
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCATT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTCTGCGAGCGTATATCCTGTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTAACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTTGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCATTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCGACCAAATCTATAGAGCTACTTTTTACACCAGACGATTAA
Antitoxin
Download Length: 269 a.a. Molecular weight: 29217.14 Da Isoelectric Point: 5.1557
>AT239372 WP_034351506.1 NZ_CP094238:c5233833-5233027 [Comamonas sp. 7D-2]
MSETSEISTNEQDRYTVPALDRGLRLLACFGPAQPVWSAPELARSLELPRSTVFRMLTTLENSGYLQRSGTEYRLGLAVL
RLGYDYLSTQPLAQLAEPVLQALCDELGMTSNLALRDGTSVVYVARVTPSGAFQGAVRVGSRLPAHATVLGRALLHDMDG
AQLRSVFGGEELPQFSESTPRNVDELLRLLAEDRERGYAMGEGFYEPGVSSIAAPVRAADGQVVAGLAMAIPFTELGPEK
TQLWVQKVQQAAETLSAHLRQQHPDHLR
MSETSEISTNEQDRYTVPALDRGLRLLACFGPAQPVWSAPELARSLELPRSTVFRMLTTLENSGYLQRSGTEYRLGLAVL
RLGYDYLSTQPLAQLAEPVLQALCDELGMTSNLALRDGTSVVYVARVTPSGAFQGAVRVGSRLPAHATVLGRALLHDMDG
AQLRSVFGGEELPQFSESTPRNVDELLRLLAEDRERGYAMGEGFYEPGVSSIAAPVRAADGQVVAGLAMAIPFTELGPEK
TQLWVQKVQQAAETLSAHLRQQHPDHLR
Download Length: 807 bp
>AT239372 NZ_LR890693:c2937938-2937672 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATTGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCACTGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA
ATGTCTGCTGTTAAAAAGCAGCGTATTGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCACTGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5D9AYH5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A096DUZ8 |