Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-couple_hipB |
| Location | 2639734..2641303 | Replicon | chromosome |
| Accession | NZ_CP094238 | ||
| Organism | Comamonas sp. 7D-2 | ||
Toxin (Protein)
| Gene name | HipA1 | Uniprot ID | A0A5D9ALV0 |
| Locus tag | MPZ60_RS12100 | Protein ID | WP_034355871.1 |
| Coordinates | 2640005..2641303 (+) | Length | 433 a.a. |
Antitoxin (Protein)
| Gene name | HipB1 | Uniprot ID | A0A5D9ANP1 |
| Locus tag | MPZ60_RS12095 | Protein ID | WP_034355868.1 |
| Coordinates | 2639734..2640015 (+) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MPZ60_RS12080 (MPZ60_12080) | 2634806..2636488 | + | 1683 | WP_034355859.1 | dihydrolipoyllysine-residue acetyltransferase | - |
| MPZ60_RS12085 (MPZ60_12085) | 2636604..2637479 | + | 876 | WP_034355862.1 | hypothetical protein | - |
| MPZ60_RS12090 (MPZ60_12090) | 2637572..2639410 | + | 1839 | WP_034355865.1 | dihydrolipoyl dehydrogenase | - |
| MPZ60_RS12095 (MPZ60_12095) | 2639734..2640015 | + | 282 | WP_034355868.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| MPZ60_RS12100 (MPZ60_12100) | 2640005..2641303 | + | 1299 | WP_034355871.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| MPZ60_RS12105 (MPZ60_12105) | 2641539..2642015 | + | 477 | WP_080746107.1 | GFA family protein | - |
| MPZ60_RS12110 (MPZ60_12110) | 2642148..2643518 | - | 1371 | WP_034355877.1 | MFS transporter | - |
| MPZ60_RS12115 (MPZ60_12115) | 2644281..2644637 | - | 357 | WP_034355880.1 | zinc ribbon domain-containing protein YjdM | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 2517267..2921695 | 404428 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 433 a.a. Molecular weight: 46957.96 Da Isoelectric Point: 7.2604
>T239369 WP_034355871.1 NZ_CP094238:2640005-2641303 [Comamonas sp. 7D-2]
MTHELEVWLFERRVGSLSLVHGRLSFAYATEWLALPQATALSQSLPLQAEPFGDHQTRPFFAGLLPEGQMRRLIAQQFQV
SGQNDFALLDHIGGECAGAVTFLEPGQALPQTDGAGATRESGDVEWLSDQKLLALLDELPRRPMLAGDDGLRLSLAGAQD
KLPVVVDDSIPGAVRIGLPRNGAPSSHILKPAIHAVEDSVANEGFCMLLAQVMGLRPANARIQSVLGRSFLLVKRYDRVL
KDDAQGQAQLQRLHQEDFCQALGVVPELKYQNEGGPGLAQCFALARSVTRPSAPQVLRLLDGVIFNALIGNHDAHGKNFS
LLYGGRAPVLAPFYDLLATAIYPQLTPKMAMKIGSKYKFSELEARHWEQFAEEAGLAKAATSKRLQQLANELPAAARKLQ
AAPPHGFAGNAVVTQIVQLIEQRCALTLRRLA
MTHELEVWLFERRVGSLSLVHGRLSFAYATEWLALPQATALSQSLPLQAEPFGDHQTRPFFAGLLPEGQMRRLIAQQFQV
SGQNDFALLDHIGGECAGAVTFLEPGQALPQTDGAGATRESGDVEWLSDQKLLALLDELPRRPMLAGDDGLRLSLAGAQD
KLPVVVDDSIPGAVRIGLPRNGAPSSHILKPAIHAVEDSVANEGFCMLLAQVMGLRPANARIQSVLGRSFLLVKRYDRVL
KDDAQGQAQLQRLHQEDFCQALGVVPELKYQNEGGPGLAQCFALARSVTRPSAPQVLRLLDGVIFNALIGNHDAHGKNFS
LLYGGRAPVLAPFYDLLATAIYPQLTPKMAMKIGSKYKFSELEARHWEQFAEEAGLAKAATSKRLQQLANELPAAARKLQ
AAPPHGFAGNAVVTQIVQLIEQRCALTLRRLA
Download Length: 1299 bp
>T239369 NZ_LR890693:2403101-2403478 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCAGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCAGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA
Antitoxin
Download Length: 94 a.a. Molecular weight: 9560.77 Da Isoelectric Point: 5.0093
>AT239369 WP_034355868.1 NZ_CP094238:2639734-2640015 [Comamonas sp. 7D-2]
MSTIHTTDQLGTALRIARKQLGLTQPQLALAAGVGTRFIVDLESGKPTVRLEHVLRVIDALGGELQLGGLPEAAHEDGAG
QAAAATEGADHDA
MSTIHTTDQLGTALRIARKQLGLTQPQLALAAGVGTRFIVDLESGKPTVRLEHVLRVIDALGGELQLGGLPEAAHEDGAG
QAAAATEGADHDA
Download Length: 282 bp
>AT239369 NZ_LR890693:2402644-2403012 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCTCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCTGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGTACCATCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACCGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCTCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCTGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGTACCATCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACCGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5D9ALV0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5D9ANP1 |