Detailed information of TA system TA239368

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 1954993..1955671
• Replicon: chromosome
• Accession: NZ_CP094238
• Organism: Comamonas sp. 7D-2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A0L7MPR3
• Locus tag: MPZ60_RS09035
• Protein ID: WP_053282542.1
• Coordinates: 1955495..1955671 (-)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: MPZ60_RS09030
• Protein ID: WP_242881762.1
• Coordinates: 1954993..1955430 (-)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPZ60_RS08995 (MPZ60_08995)	1950877..1951632	+	756	WP_242881771.1	hypothetical protein	-
MPZ60_RS09000 (MPZ60_09000)	1951629..1952867	+	1239	WP_242881769.1	hypothetical protein	-
MPZ60_RS09005 (MPZ60_09005)	1953038..1953433	+	396	WP_242881767.1	hypothetical protein	-
MPZ60_RS09010 (MPZ60_09010)	1953436..1953726	+	291	WP_242881765.1	hypothetical protein	-
MPZ60_RS09015 (MPZ60_09015)	1953737..1954054	+	318	WP_242881764.1	hypothetical protein	-
MPZ60_RS09020 (MPZ60_09020)	1954051..1954521	+	471	WP_045839658.1	lysozyme	-
MPZ60_RS09025 (MPZ60_09025)	1954518..1955012	+	495	WP_242881763.1	hypothetical protein	-
MPZ60_RS09030 (MPZ60_09030)	1954993..1955430	-	438	WP_242881762.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
MPZ60_RS09035 (MPZ60_09035)	1955495..1955671	-	177	WP_053282542.1	type II toxin-antitoxin system HicA family toxin	Toxin
MPZ60_RS09040 (MPZ60_09040)	1955757..1955969	-	213	WP_242881761.1	hypothetical protein	-
MPZ60_RS09045 (MPZ60_09045)	1955969..1957267	-	1299	WP_242881760.1	Y-family DNA polymerase	-
MPZ60_RS09050 (MPZ60_09050)	1957274..1957687	-	414	WP_242881758.1	translesion error-prone DNA polymerase V autoproteolytic subunit	-
MPZ60_RS09055 (MPZ60_09055)	1957804..1959456	-	1653	WP_242881756.1	recombinase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1907096..1968350	61254

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-63)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6599.73 Da
• Isoelectric Point: 11.7505

>T239368 WP_053282542.1 NZ_CP094238:c1955671-1955495 [Comamonas sp. 7D-2]
MKQSEFQRWLAAQGATFSHGTRHLKVFLNGKQTIMPRHPSQEIGEGLRKAILKQLGLK

Nucleotide

• Length: 177 bp

>T239368 NZ_LR890693:c2260678-2260271 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 15657.01 Da
• Isoelectric Point: 5.2039

>AT239368 WP_242881762.1 NZ_CP094238:c1955430-1954993 [Comamonas sp. 7D-2]
MRFPANIEPDGDGFMVSFPDIPEALTCGDTYDEAVSMAHDALLTAMDFYFDDRRAVPEPSKAAKGQVLISLPASVSAKVL
LLNEMVHQGVRPIDLAARMGTTKQEVNRLTDLKHATKIDTIAKALATMGLDLELGVRRSATAAAR

Nucleotide

• Length: 438 bp

>AT239368 NZ_LR890693:c2260925-2260659 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCACCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: A0A0L7MPR3