Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1793180..1793850 Replicon chromosome
Accession NZ_CP094238
Organism Comamonas sp. 7D-2

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag MPZ60_RS08260 Protein ID WP_242881849.1
Coordinates 1793674..1793850 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag MPZ60_RS08255 Protein ID WP_242881850.1
Coordinates 1793180..1793608 (-) Length 143 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPZ60_RS08225 (MPZ60_08225) 1789337..1789732 + 396 WP_242881856.1 hypothetical protein -
MPZ60_RS08230 (MPZ60_08230) 1789732..1791627 + 1896 WP_242881855.1 hypothetical protein -
MPZ60_RS08235 (MPZ60_08235) 1791624..1791860 + 237 WP_242881854.1 hypothetical protein -
MPZ60_RS08240 (MPZ60_08240) 1791892..1792209 + 318 WP_242881853.1 hypothetical protein -
MPZ60_RS08245 (MPZ60_08245) 1792206..1792676 + 471 WP_242881852.1 lysozyme -
MPZ60_RS08250 (MPZ60_08250) 1792673..1793167 + 495 WP_242881851.1 hypothetical protein -
MPZ60_RS08255 (MPZ60_08255) 1793180..1793608 - 429 WP_242881850.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
MPZ60_RS08260 (MPZ60_08260) 1793674..1793850 - 177 WP_242881849.1 type II toxin-antitoxin system HicA family toxin Toxin
MPZ60_RS08265 (MPZ60_08265) 1793929..1794141 - 213 WP_242881848.1 hypothetical protein -
MPZ60_RS08270 (MPZ60_08270) 1794141..1795439 - 1299 WP_242881847.1 Y-family DNA polymerase -
MPZ60_RS08275 (MPZ60_08275) 1795449..1796306 - 858 WP_242881846.1 excinuclease Cho -
MPZ60_RS08280 (MPZ60_08280) 1796311..1796727 - 417 WP_242881844.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
MPZ60_RS08290 (MPZ60_08290) 1797121..1797934 - 814 Protein_1599 IS5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1724227..1803731 79504


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-73)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6737.70 Da        Isoelectric Point: 11.0738

>T239367 WP_242881849.1 NZ_CP094238:c1793850-1793674 [Comamonas sp. 7D-2]
VKISEFKRWLEAQGVKVENGTNHWRLYHNGNTSTLPRHPSKELKEGTRRAILKQLGIN

Download         Length: 177 bp

>T239367 NZ_LR890693:c1304441-1304190 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGACAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 143 a.a.        Molecular weight: 15238.48 Da        Isoelectric Point: 4.8066

>AT239367 WP_242881850.1 NZ_CP094238:c1793608-1793180 [Comamonas sp. 7D-2]
MQKYPARFDPADEGGYTVTFRDIPEAITQGDDLAEAESMARDALVTAMEFYFEAGRAVPAPSKAEKGERLVELPASVAVK
VALLNARLATGARPADVARAMGVKPQEMTRVFDLGHATKIDTVAAALAAMGYELELTVRPIK

Download         Length: 429 bp

>AT239367 NZ_LR890693:c1304193-1303939 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAGCAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAACTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCTTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References