Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4851753..4852269 Replicon chromosome
Accession NZ_CP094237
Organism Klebsiella pneumoniae strain K41

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag MQE26_RS23705 Protein ID WP_009486548.1
Coordinates 4851753..4852037 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag MQE26_RS23710 Protein ID WP_002886901.1
Coordinates 4852027..4852269 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQE26_RS23680 (MQE26_23680) 4847170..4847433 - 264 WP_025368518.1 PTS sugar transporter subunit IIB -
MQE26_RS23685 (MQE26_23685) 4847563..4847736 + 174 WP_002886906.1 hypothetical protein -
MQE26_RS23690 (MQE26_23690) 4847739..4848482 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
MQE26_RS23695 (MQE26_23695) 4848839..4850977 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
MQE26_RS23700 (MQE26_23700) 4851285..4851749 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MQE26_RS23705 (MQE26_23705) 4851753..4852037 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MQE26_RS23710 (MQE26_23710) 4852027..4852269 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MQE26_RS23715 (MQE26_23715) 4852347..4854257 - 1911 WP_031593171.1 PRD domain-containing protein -
MQE26_RS23720 (MQE26_23720) 4854280..4855434 - 1155 WP_004178372.1 lactonase family protein -
MQE26_RS23725 (MQE26_23725) 4855501..4856241 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T239364 WP_009486548.1 NZ_CP094237:c4852037-4851753 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T239364 NZ_LR890693:c987434-987332 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT239364 WP_002886901.1 NZ_CP094237:c4852269-4852027 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT239364 NZ_LR890693:987294-987562 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATATTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References