Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 1497873..1498609 | Replicon | chromosome |
| Accession | NZ_CP094237 | ||
| Organism | Klebsiella pneumoniae strain K41 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | - |
| Locus tag | MQE26_RS07420 | Protein ID | WP_077269838.1 |
| Coordinates | 1498127..1498609 (+) | Length | 161 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | L7SZ29 |
| Locus tag | MQE26_RS07415 | Protein ID | WP_003026799.1 |
| Coordinates | 1497873..1498139 (+) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MQE26_RS07365 (MQE26_07365) | 1493414..1493824 | - | 411 | WP_064147997.1 | heme-binding protein | - |
| MQE26_RS07370 (MQE26_07370) | 1493905..1494102 | - | 198 | WP_232554891.1 | IclR family transcriptional regulator C-terminal domain-containing protein | - |
| MQE26_RS07375 (MQE26_07375) | 1494146..1494583 | - | 438 | WP_228715803.1 | helix-turn-helix domain-containing protein | - |
| MQE26_RS07380 (MQE26_07380) | 1495061..1495324 | + | 264 | WP_004118691.1 | hypothetical protein | - |
| MQE26_RS07385 (MQE26_07385) | 1495321..1495887 | + | 567 | WP_242898415.1 | hypothetical protein | - |
| MQE26_RS07390 (MQE26_07390) | 1495918..1496412 | + | 495 | WP_242898416.1 | DNA-binding protein | - |
| MQE26_RS07395 (MQE26_07395) | 1496456..1496824 | + | 369 | WP_122462932.1 | hypothetical protein | - |
| MQE26_RS07400 (MQE26_07400) | 1496858..1497061 | + | 204 | WP_004152106.1 | HHA domain-containing protein | - |
| MQE26_RS07405 (MQE26_07405) | 1497110..1497367 | + | 258 | WP_004098928.1 | hypothetical protein | - |
| MQE26_RS07410 (MQE26_07410) | 1497443..1497697 | + | 255 | WP_004118702.1 | hypothetical protein | - |
| MQE26_RS07415 (MQE26_07415) | 1497873..1498139 | + | 267 | WP_003026799.1 | DUF1778 domain-containing protein | Antitoxin |
| MQE26_RS07420 (MQE26_07420) | 1498127..1498609 | + | 483 | WP_077269838.1 | GNAT family N-acetyltransferase | Toxin |
| MQE26_RS07425 (MQE26_07425) | 1498820..1500166 | + | 1347 | WP_077264206.1 | ISNCY family transposase | - |
| MQE26_RS07430 (MQE26_07430) | 1500220..1500411 | - | 192 | WP_060589184.1 | hypothetical protein | - |
| MQE26_RS07435 (MQE26_07435) | 1500862..1501461 | - | 600 | WP_032432064.1 | helix-turn-helix transcriptional regulator | - |
| MQE26_RS07440 (MQE26_07440) | 1501674..1502618 | - | 945 | WP_077256325.1 | fimbrial protein | - |
| MQE26_RS07445 (MQE26_07445) | 1502630..1503208 | - | 579 | WP_032432061.1 | type 1 fimbrial protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | iutA / iucD / iucC / iucB / iucA | 1418077..1511443 | 93366 | |
| - | flank | IS/Tn | - | - | 1499327..1500166 | 839 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 161 a.a. Molecular weight: 17378.94 Da Isoelectric Point: 9.6047
>T239349 WP_077269838.1 NZ_CP094237:1498127-1498609 [Klebsiella pneumoniae]
VGRITAPEPLSSSHQRAEFVSGETVLDEWLKHRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYTHHGFTASQTHERTLFLKLP
VGRITAPEPLSSSHQRAEFVSGETVLDEWLKHRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYTHHGFTASQTHERTLFLKLP
Download Length: 483 bp
>T239349 NZ_LR890691:356546-356893 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 10147.59 Da Isoelectric Point: 4.5256
>AT239349 WP_003026799.1 NZ_CP094237:1497873-1498139 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV
Download Length: 267 bp
>AT239349 NZ_LR890691:356893-357192 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCAGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCAGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|