Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 1469992..1470635 | Replicon | chromosome |
| Accession | NZ_CP094237 | ||
| Organism | Klebsiella pneumoniae strain K41 | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | - |
| Locus tag | MQE26_RS07235 | Protein ID | WP_069985717.1 |
| Coordinates | 1470219..1470635 (+) | Length | 139 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | A0A6B7Q5S4 |
| Locus tag | MQE26_RS07230 | Protein ID | WP_021312476.1 |
| Coordinates | 1469992..1470222 (+) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MQE26_RS07195 (MQE26_07195) | 1465643..1466164 | - | 522 | WP_040175058.1 | hypothetical protein | - |
| MQE26_RS07200 (MQE26_07200) | 1466222..1466614 | - | 393 | WP_221014760.1 | hypothetical protein | - |
| MQE26_RS07205 (MQE26_07205) | 1466651..1467595 | - | 945 | WP_242898414.1 | hypothetical protein | - |
| MQE26_RS07210 (MQE26_07210) | 1467795..1468004 | - | 210 | Protein_1407 | hypothetical protein | - |
| MQE26_RS07215 (MQE26_07215) | 1468141..1468830 | + | 690 | WP_004193995.1 | hypothetical protein | - |
| MQE26_RS07220 (MQE26_07220) | 1468862..1469551 | - | 690 | WP_069985716.1 | RES family NAD+ phosphorylase | - |
| MQE26_RS07225 (MQE26_07225) | 1469778..1470035 | - | 258 | Protein_1410 | hypothetical protein | - |
| MQE26_RS07230 (MQE26_07230) | 1469992..1470222 | + | 231 | WP_021312476.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| MQE26_RS07235 (MQE26_07235) | 1470219..1470635 | + | 417 | WP_069985717.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| MQE26_RS07240 (MQE26_07240) | 1470842..1471771 | + | 930 | WP_105910612.1 | Rpn family recombination-promoting nuclease/putative transposase | - |
| MQE26_RS07245 (MQE26_07245) | 1471768..1472379 | - | 612 | WP_105910594.1 | DUF2913 family protein | - |
| MQE26_RS07250 (MQE26_07250) | 1472376..1472771 | - | 396 | WP_105910593.1 | hypothetical protein | - |
| MQE26_RS07255 (MQE26_07255) | 1472824..1473381 | - | 558 | Protein_1416 | 3'-5' exonuclease | - |
| MQE26_RS07260 (MQE26_07260) | 1473553..1474557 | + | 1005 | WP_000427619.1 | IS110-like element IS5075 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | iutA / iucD / iucC / iucB / iucA | 1418077..1511443 | 93366 | |
| - | flank | IS/Tn | - | - | 1473553..1474557 | 1004 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 14989.47 Da Isoelectric Point: 9.2738
>T239347 WP_069985717.1 NZ_CP094237:1470219-1470635 [Klebsiella pneumoniae]
VKKTFMLDTNICSFIMREQPAAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHIELVDAFCARLDAILPWDRA
AVDATTEIKVALRQAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLVLEDWVK
VKKTFMLDTNICSFIMREQPAAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHIELVDAFCARLDAILPWDRA
AVDATTEIKVALRQAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLVLEDWVK
Download Length: 417 bp
>T239347 NZ_LR890687:c148484-148002 [Klebsiella pneumoniae]
ATGGGAATGAGAGCGCCTGAATCCCTGACGTCTGAACATAACATCGCTGAGTTCTGCTGCCAGGAGCCTGCCCTTAATGA
GTGGTTAAAGAAGAAGGCTCTCAGAAACCACAGTACCGGCATTTCCCGTGTCTATGTCGTCTGCGCAGAAAACACTAACC
GGGTCATCGGTTATTATTGTTTATCTTCGGGTAGCGTCCACCGTAACACAGTGCCTGGGGCCTATAGACGCAACGCGCCT
GATGTTATTCCAGTCATTGTTTTGGGACGGCTTGCCATCGACCAGGCCTGGTCCGGGAATGGGCTTGGTGCCGCACTTCT
TAAGGATGCTATATACCGTACGCAAAACATTGCCTTTCAGGTCGGGGTGAGAGCACTGGCAGTGCATGCGCTGAATGAAG
AAGTTAAATGTTTTTACACCCGTTTTGGCTTTGAGCCTTCCATAGTCAACACGCTGACATTGTTATTCCCGATAAAAGTC
TGA
ATGGGAATGAGAGCGCCTGAATCCCTGACGTCTGAACATAACATCGCTGAGTTCTGCTGCCAGGAGCCTGCCCTTAATGA
GTGGTTAAAGAAGAAGGCTCTCAGAAACCACAGTACCGGCATTTCCCGTGTCTATGTCGTCTGCGCAGAAAACACTAACC
GGGTCATCGGTTATTATTGTTTATCTTCGGGTAGCGTCCACCGTAACACAGTGCCTGGGGCCTATAGACGCAACGCGCCT
GATGTTATTCCAGTCATTGTTTTGGGACGGCTTGCCATCGACCAGGCCTGGTCCGGGAATGGGCTTGGTGCCGCACTTCT
TAAGGATGCTATATACCGTACGCAAAACATTGCCTTTCAGGTCGGGGTGAGAGCACTGGCAGTGCATGCGCTGAATGAAG
AAGTTAAATGTTTTTACACCCGTTTTGGCTTTGAGCCTTCCATAGTCAACACGCTGACATTGTTATTCCCGATAAAAGTC
TGA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8723.76 Da Isoelectric Point: 4.3410
>AT239347 WP_021312476.1 NZ_CP094237:1469992-1470222 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFDL
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFDL
Download Length: 231 bp
>AT239347 NZ_LR890687:c148753-148475 [Klebsiella pneumoniae]
ATGAAACCAGACGTTCGTGAAGCGCCGATTAATATTCGGGCCAAAACATCACAGCGTGACCTGATCGACATGGCCGCAAG
CCTGGTCTCAAAATCACGGACTGATTTTATGCTTGAGGTTGCCTGCAGGGAGGCACAGGACATTCTGCTTGATCAACGCC
TGTTCCTCCTCAATGACAATCAGTTTGAGACGTTTATTGAAGAGCTTGACGCCCCAATAACGCCGGAGCGCCAGGCGCGA
ATCGATAACCTGATGAACCGCAAATCACCATGGGAATGA
ATGAAACCAGACGTTCGTGAAGCGCCGATTAATATTCGGGCCAAAACATCACAGCGTGACCTGATCGACATGGCCGCAAG
CCTGGTCTCAAAATCACGGACTGATTTTATGCTTGAGGTTGCCTGCAGGGAGGCACAGGACATTCTGCTTGATCAACGCC
TGTTCCTCCTCAATGACAATCAGTTTGAGACGTTTATTGAAGAGCTTGACGCCCCAATAACGCCGGAGCGCCAGGCGCGA
ATCGATAACCTGATGAACCGCAAATCACCATGGGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|