Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 792631..793288 Replicon chromosome
Accession NZ_CP094237
Organism Klebsiella pneumoniae strain K41

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag MQE26_RS03940 Protein ID WP_002916310.1
Coordinates 792878..793288 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag MQE26_RS03935 Protein ID WP_002916312.1
Coordinates 792631..792897 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQE26_RS03910 (MQE26_03910) 787787..789220 - 1434 WP_040219565.1 6-phospho-beta-glucosidase -
MQE26_RS03915 (MQE26_03915) 789339..790067 - 729 WP_117053803.1 MurR/RpiR family transcriptional regulator -
MQE26_RS03920 (MQE26_03920) 790117..790428 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
MQE26_RS03925 (MQE26_03925) 790592..791251 + 660 WP_002916317.1 hemolysin III family protein -
MQE26_RS03930 (MQE26_03930) 791402..792385 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
MQE26_RS03935 (MQE26_03935) 792631..792897 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
MQE26_RS03940 (MQE26_03940) 792878..793288 + 411 WP_002916310.1 protein YgfX Toxin
MQE26_RS03945 (MQE26_03945) 793295..793816 - 522 WP_004144730.1 flavodoxin FldB -
MQE26_RS03950 (MQE26_03950) 793917..794813 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
MQE26_RS03955 (MQE26_03955) 794836..795549 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MQE26_RS03960 (MQE26_03960) 795555..797288 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T239346 WP_002916310.1 NZ_CP094237:792878-793288 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T239346 NZ_LR890687:28917-29402 [Klebsiella pneumoniae]
GTGGGACGTATAACCGCGCCCGAACCGTTATTCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCGCGGAAAAGGGCTTGGCGCTGATTT
ACTTCATGATGCAGTACTTCGTTGCTATCGGGTTGCCGAGAATATAGGTGTACGTGCAATCATGGTTCATGCGCTCACAG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAACCATCACAAACTCAGCCGCGGACACTGTTCCTCAGACTCCCT
CAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT239346 WP_002916312.1 NZ_CP094237:792631-792897 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT239346 NZ_LR890687:28663-28929 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAGCTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCTCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References