Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/PRK09907-MazE |
| Location | 118405..119012 | Replicon | plasmid pNY13320-1 |
| Accession | NZ_CP094231 | ||
| Organism | Enterococcus faecium strain NY13320 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | E3USU0 |
| Locus tag | MPN36_RS14495 | Protein ID | WP_002321032.1 |
| Coordinates | 118405..118755 (-) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | A0A829F3C0 |
| Locus tag | MPN36_RS14500 | Protein ID | WP_002287514.1 |
| Coordinates | 118749..119012 (-) | Length | 88 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MPN36_RS14460 (MPN36_14460) | 113781..114413 | - | 633 | WP_010729807.1 | HAD family phosphatase | - |
| MPN36_RS14465 (MPN36_14465) | 114426..115079 | - | 654 | Protein_124 | PRD domain-containing protein | - |
| MPN36_RS14470 (MPN36_14470) | 115154..115834 | + | 681 | WP_002331383.1 | IS6-like element IS1216 family transposase | - |
| MPN36_RS14475 (MPN36_14475) | 116023..116607 | - | 585 | WP_002299575.1 | recombinase family protein | - |
| MPN36_RS14480 (MPN36_14480) | 116818..117021 | - | 204 | WP_002299573.1 | hypothetical protein | - |
| MPN36_RS14485 (MPN36_14485) | 117031..117453 | - | 423 | WP_002288787.1 | hypothetical protein | - |
| MPN36_RS14490 (MPN36_14490) | 117767..118381 | + | 615 | WP_010782739.1 | recombinase family protein | - |
| MPN36_RS14495 (MPN36_14495) | 118405..118755 | - | 351 | WP_002321032.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| MPN36_RS14500 (MPN36_14500) | 118749..119012 | - | 264 | WP_002287514.1 | hypothetical protein | Antitoxin |
| MPN36_RS14505 (MPN36_14505) | 119353..119532 | - | 180 | WP_002305761.1 | hypothetical protein | - |
| MPN36_RS14510 (MPN36_14510) | 119548..119748 | - | 201 | WP_002330566.1 | hypothetical protein | - |
| MPN36_RS14515 (MPN36_14515) | 119913..120620 | - | 708 | WP_002353391.1 | hypothetical protein | - |
| MPN36_RS14520 (MPN36_14520) | 120613..121050 | - | 438 | WP_002296237.1 | hypothetical protein | - |
| MPN36_RS14525 (MPN36_14525) | 121065..121316 | - | 252 | WP_002296238.1 | hypothetical protein | - |
| MPN36_RS14530 (MPN36_14530) | 121316..121522 | - | 207 | WP_002296239.1 | hypothetical protein | - |
| MPN36_RS14535 (MPN36_14535) | 121963..122223 | - | 261 | WP_002296240.1 | hypothetical protein | - |
| MPN36_RS14540 (MPN36_14540) | 122589..123074 | - | 486 | WP_002296241.1 | single-stranded DNA-binding protein | - |
| MPN36_RS14545 (MPN36_14545) | 123077..123976 | - | 900 | WP_002322787.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..181403 | 181403 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 13255.28 Da Isoelectric Point: 8.0280
>T239342 WP_002321032.1 NZ_CP094231:c118755-118405 [Enterococcus faecium]
MVRKPRQGDILLLNTAPRSGHEQTGKRPYIVLSHDIIADYSNVVTVAPISSTTRNYPLYVNINSEYEMKTTGKVLLDQLT
TIDYEARECIFLEKAHDSLVEELLMKVRTVFQKVSK
MVRKPRQGDILLLNTAPRSGHEQTGKRPYIVLSHDIIADYSNVVTVAPISSTTRNYPLYVNINSEYEMKTTGKVLLDQLT
TIDYEARECIFLEKAHDSLVEELLMKVRTVFQKVSK
Download Length: 351 bp
>T239342 NZ_LR890686:c4729823-4729539 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCAGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA
ATGACCTATGAACTGGAGTTTGATCCACGAGCCAGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA
Antitoxin
Download Length: 88 a.a. Molecular weight: 10183.60 Da Isoelectric Point: 4.6865
>AT239342 WP_002287514.1 NZ_CP094231:c119012-118749 [Enterococcus faecium]
MEMLPIKKWGNSNGLRLPKYIMEYLGIHTEDKVKIIQEEVNGQKRLIIEAANIENELTIEQLFENYTDERNHVTIQNLGE
AVGNEKW
MEMLPIKKWGNSNGLRLPKYIMEYLGIHTEDKVKIIQEEVNGQKRLIIEAANIENELTIEQLFENYTDERNHVTIQNLGE
AVGNEKW
Download Length: 264 bp
>AT239342 NZ_LR890686:c4730055-4729813 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829F5H8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829F3C0 |