Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicB-HicA |
| Location | 96521..97138 | Replicon | plasmid pNY13320-1 |
| Accession | NZ_CP094231 | ||
| Organism | Enterococcus faecium strain NY13320 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | MPN36_RS14330 | Protein ID | WP_224451579.1 |
| Coordinates | 96986..97138 (-) | Length | 51 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | A0A829EWE8 |
| Locus tag | MPN36_RS14325 | Protein ID | WP_002305052.1 |
| Coordinates | 96521..96952 (-) | Length | 144 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MPN36_RS14310 (MPN36_14310) | 92336..93763 | - | 1428 | WP_002361237.1 | glycoside hydrolase family 32 protein | - |
| MPN36_RS14315 (MPN36_14315) | 93817..95091 | - | 1275 | WP_002323715.1 | MFS transporter | - |
| MPN36_RS14320 (MPN36_14320) | 95394..96347 | + | 954 | WP_002325884.1 | IS30 family transposase | - |
| MPN36_RS14325 (MPN36_14325) | 96521..96952 | - | 432 | WP_002305052.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| MPN36_RS14330 (MPN36_14330) | 96986..97138 | - | 153 | WP_224451579.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| MPN36_RS14335 (MPN36_14335) | 97232..97411 | - | 180 | Protein_98 | hypothetical protein | - |
| MPN36_RS14340 (MPN36_14340) | 97427..97627 | - | 201 | WP_002324500.1 | hypothetical protein | - |
| MPN36_RS14345 (MPN36_14345) | 97792..98487 | - | 696 | WP_002305050.1 | hypothetical protein | - |
| MPN36_RS14350 (MPN36_14350) | 98480..98917 | - | 438 | WP_002326156.1 | hypothetical protein | - |
| MPN36_RS14355 (MPN36_14355) | 98933..99184 | - | 252 | WP_002287517.1 | hypothetical protein | - |
| MPN36_RS14360 (MPN36_14360) | 99184..99390 | - | 207 | WP_002296239.1 | hypothetical protein | - |
| MPN36_RS14365 (MPN36_14365) | 99839..100063 | - | 225 | WP_074399798.1 | hypothetical protein | - |
| MPN36_RS14370 (MPN36_14370) | 100231..100375 | + | 145 | Protein_105 | type I toxin-antitoxin system toxin PepG1 | - |
| MPN36_RS14375 (MPN36_14375) | 100534..100791 | - | 258 | WP_002295625.1 | hypothetical protein | - |
| MPN36_RS14380 (MPN36_14380) | 100813..101298 | - | 486 | Protein_107 | single-stranded DNA-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..181403 | 181403 | |
| - | flank | IS/Tn | - | - | 95394..96347 | 953 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 51 a.a. Molecular weight: 5815.65 Da Isoelectric Point: 10.3560
>T239341 WP_224451579.1 NZ_CP094231:c97138-96986 [Enterococcus faecium]
IEKNGWVERRQEGFHHHLYKDGVRITVPVHANQDLGRGLERKILKDAGLK
IEKNGWVERRQEGFHHHLYKDGVRITVPVHANQDLGRGLERKILKDAGLK
Download Length: 153 bp
>T239341 NZ_LR890686:c4613247-4612714 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
Antitoxin
Download Length: 144 a.a. Molecular weight: 15811.92 Da Isoelectric Point: 4.1638
>AT239341 WP_002305052.1 NZ_CP094231:c96952-96521 [Enterococcus faecium]
MLSEPLAKTYPAIFSPEEGGGYFIEFPDVQGAYTGINEDDISYGIAMAQEVLGMVLADYIEHEDLLPEPTPINKISVEDD
SFTTLIRVDVAKYLKDTELVKKTLTIPQWADKLGKRAGINFSVLLTESIADKADNILRSGRNN
MLSEPLAKTYPAIFSPEEGGGYFIEFPDVQGAYTGINEDDISYGIAMAQEVLGMVLADYIEHEDLLPEPTPINKISVEDD
SFTTLIRVDVAKYLKDTELVKKTLTIPQWADKLGKRAGINFSVLLTESIADKADNILRSGRNN
Download Length: 432 bp
>AT239341 NZ_LR890686:c4613524-4613258 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|