Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | stbDE/ParE-YafN |
Location | 227259..227781 | Replicon | plasmid pBio3 |
Accession | NZ_CP094228 | ||
Organism | Klebsiella pneumoniae strain Bio3 |
Toxin (Protein)
Gene name | stbE | Uniprot ID | A0A0C7KG00 |
Locus tag | MOO48_RS29230 | Protein ID | WP_038991638.1 |
Coordinates | 227259..227543 (-) | Length | 95 a.a. |
Antitoxin (Protein)
Gene name | stbD | Uniprot ID | A0A2J4R0U8 |
Locus tag | MOO48_RS29235 | Protein ID | WP_004181777.1 |
Coordinates | 227533..227781 (-) | Length | 83 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MOO48_RS29195 (MOO48_29195) | 222896..223240 | + | 345 | WP_014386518.1 | hypothetical protein | - |
MOO48_RS29200 (MOO48_29200) | 223237..223608 | + | 372 | WP_044816264.1 | hypothetical protein | - |
MOO48_RS29205 (MOO48_29205) | 223653..224840 | - | 1188 | WP_043907031.1 | RNA-guided endonuclease TnpB family protein | - |
MOO48_RS29210 (MOO48_29210) | 224876..225304 | + | 429 | WP_077256229.1 | IS200/IS605 family transposase | - |
MOO48_RS29215 (MOO48_29215) | 225383..225607 | + | 225 | Protein_240 | transposase | - |
MOO48_RS29220 (MOO48_29220) | 225879..227105 | - | 1227 | WP_040120327.1 | RNA-guided endonuclease TnpB family protein | - |
MOO48_RS29225 (MOO48_29225) | 227141..227242 | + | 102 | Protein_242 | IS200/IS605 family transposase | - |
MOO48_RS29230 (MOO48_29230) | 227259..227543 | - | 285 | WP_038991638.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
MOO48_RS29235 (MOO48_29235) | 227533..227781 | - | 249 | WP_004181777.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
MOO48_RS29240 (MOO48_29240) | 228072..229871 | + | 1800 | WP_043907032.1 | ATP-dependent helicase | - |
MOO48_RS29245 (MOO48_29245) | 230205..231191 | + | 987 | WP_040120328.1 | hypothetical protein | - |
MOO48_RS29250 (MOO48_29250) | 231336..231689 | + | 354 | WP_004181774.1 | hypothetical protein | - |
MOO48_RS29255 (MOO48_29255) | 231751..232572 | + | 822 | WP_004181772.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | mph(E) / msr(E) / armA / sul1 / qacE / aadA2 / dfrA12 / blaTEM-1A / blaOXA-232 / dfrA14 / tet(D) / aac(6')-Ib-cr / blaOXA-1 / blaCTX-M-15 | rmpA / iutA / iucD / iucC / iucB / iucA | 1..328083 | 328083 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 95 a.a. Molecular weight: 10993.73 Da Isoelectric Point: 10.6516
>T239338 WP_038991638.1 NZ_CP094228:c227543-227259 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYHLTKHRN
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYHLTKHRN
Download Length: 285 bp
>T239338 NZ_LR890686:1967870-1967972 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
Antitoxin
Download Length: 83 a.a. Molecular weight: 8925.17 Da Isoelectric Point: 3.8209
>AT239338 WP_004181777.1 NZ_CP094228:c227781-227533 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGRIADERIGEAVIEVSLD
DL
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGRIADERIGEAVIEVSLD
DL
Download Length: 249 bp
>AT239338 NZ_LR890686:c1967979-1967834 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0C7KG00 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2J4R0U8 |