Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 131301..132211 | Replicon | plasmid pBio3 |
| Accession | NZ_CP094228 | ||
| Organism | Klebsiella pneumoniae strain Bio3 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A5Q9LR54 |
| Locus tag | MOO48_RS28730 | Protein ID | WP_004181896.1 |
| Coordinates | 131301..131771 (-) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A2J4RLY9 |
| Locus tag | MOO48_RS28735 | Protein ID | WP_004181895.1 |
| Coordinates | 131768..132211 (-) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MOO48_RS28705 (MOO48_28705) | 126797..127174 | + | 378 | WP_004181901.1 | hypothetical protein | - |
| MOO48_RS28710 (MOO48_28710) | 127372..128346 | - | 975 | WP_043907013.1 | hypothetical protein | - |
| MOO48_RS28715 (MOO48_28715) | 128949..129107 | - | 159 | WP_004181898.1 | type I toxin-antitoxin system Hok family toxin | - |
| MOO48_RS28720 (MOO48_28720) | 129179..130360 | + | 1182 | WP_004883380.1 | IS481 family transposase | - |
| MOO48_RS28725 (MOO48_28725) | 130931..131191 | + | 261 | WP_004026352.1 | hypothetical protein | - |
| MOO48_RS28730 (MOO48_28730) | 131301..131771 | - | 471 | WP_004181896.1 | RES family NAD+ phosphorylase | Toxin |
| MOO48_RS28735 (MOO48_28735) | 131768..132211 | - | 444 | WP_004181895.1 | DUF2384 domain-containing protein | Antitoxin |
| MOO48_RS28740 (MOO48_28740) | 132312..133583 | - | 1272 | WP_004181894.1 | translesion error-prone DNA polymerase V subunit UmuC | - |
| MOO48_RS28745 (MOO48_28745) | 133583..134005 | - | 423 | WP_004181893.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
| MOO48_RS28750 (MOO48_28750) | 134110..134517 | + | 408 | Protein_146 | IS6-like element IS26 family transposase | - |
| MOO48_RS28755 (MOO48_28755) | 134408..134884 | - | 477 | WP_112298109.1 | hypothetical protein | - |
| MOO48_RS28760 (MOO48_28760) | 134881..135363 | - | 483 | WP_016947068.1 | hypothetical protein | - |
| MOO48_RS28765 (MOO48_28765) | 135701..136036 | - | 336 | WP_153236429.1 | hypothetical protein | - |
| MOO48_RS28770 (MOO48_28770) | 136120..136335 | - | 216 | WP_004197183.1 | hypothetical protein | - |
| MOO48_RS28775 (MOO48_28775) | 136615..137001 | - | 387 | WP_043907018.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | mph(E) / msr(E) / armA / sul1 / qacE / aadA2 / dfrA12 / blaTEM-1A / blaOXA-232 / dfrA14 / tet(D) / aac(6')-Ib-cr / blaOXA-1 / blaCTX-M-15 | rmpA / iutA / iucD / iucC / iucB / iucA | 1..328083 | 328083 | |
| - | flank | IS/Tn | - | - | 129179..130360 | 1181 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17549.81 Da Isoelectric Point: 4.6155
>T239337 WP_004181896.1 NZ_CP094228:c131771-131301 [Klebsiella pneumoniae]
VIFYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VIFYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
>T239337 NZ_LR890686:808151-808561 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA
Antitoxin
Download Length: 148 a.a. Molecular weight: 16536.87 Da Isoelectric Point: 10.3013
>AT239337 WP_004181895.1 NZ_CP094228:c132211-131768 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
>AT239337 NZ_LR890686:807904-808170 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Q9LR54 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2J4RLY9 |