Detailed information of TA system TA239331

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 5060810..5061467
• Replicon: chromosome
• Accession: NZ_CP094227
• Organism: Klebsiella pneumoniae strain Bio3

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: MOO48_RS24305
• Protein ID: WP_004181233.1
• Coordinates: 5061057..5061467 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: W8UQ37
• Locus tag: MOO48_RS24300
• Protein ID: WP_002916312.1
• Coordinates: 5060810..5061076 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOO48_RS24275 (5055966)	5055966..5057399	-	1434	WP_004181234.1	6-phospho-beta-glucosidase	-
MOO48_RS24280 (5057518)	5057518..5058246	-	729	WP_002916321.1	MurR/RpiR family transcriptional regulator	-
MOO48_RS24285 (5058296)	5058296..5058607	+	312	WP_004144734.1	N(4)-acetylcytidine aminohydrolase	-
MOO48_RS24290 (5058771)	5058771..5059430	+	660	WP_002916317.1	hemolysin III family protein	-
MOO48_RS24295 (5059581)	5059581..5060564	-	984	WP_002916313.1	tRNA-modifying protein YgfZ	-
MOO48_RS24300 (5060810)	5060810..5061076	+	267	WP_002916312.1	FAD assembly factor SdhE	Antitoxin
MOO48_RS24305 (5061057)	5061057..5061467	+	411	WP_004181233.1	protein YgfX	Toxin
MOO48_RS24310 (5061474)	5061474..5061995	-	522	WP_004144730.1	flavodoxin FldB	-
MOO48_RS24315 (5062096)	5062096..5062992	+	897	WP_004144729.1	site-specific tyrosine recombinase XerD	-
MOO48_RS24320 (5063015)	5063015..5063728	+	714	WP_002916301.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
MOO48_RS24325 (5063734)	5063734..5065467	+	1734	WP_004149758.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	4956356..5062992	106636

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16121.92 Da
• Isoelectric Point: 11.1565

>T239331 WP_004181233.1 NZ_CP094227:5061057-5061467 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAEEWRDLRRLVLQKPAQE

Nucleotide

• Length: 411 bp

>T239331 NZ_LR890680:53790-54272 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10480.98 Da
• Isoelectric Point: 5.1116

>AT239331 WP_002916312.1 NZ_CP094227:5060810-5061076 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT239331 NZ_LR890680:53536-53802 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GY41