Detailed information of TA system TA239328

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4476718..4478306
• Replicon: chromosome
• Accession: NZ_CP094227
• Organism: Klebsiella pneumoniae strain Bio3

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: MOO48_RS21490
• Protein ID: WP_004179815.1
• Coordinates: 4476984..4478306 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: MOO48_RS21485
• Protein ID: WP_004176198.1
• Coordinates: 4476718..4476984 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOO48_RS21460 (4471868)	4471868..4472791	+	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-
MOO48_RS21465 (4472772)	4472772..4473926	-	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
MOO48_RS21470 (4474272)	4474272..4475651	+	1380	WP_004179808.1	nucleobase:cation symporter-2 family protein	-
MOO48_RS21475 (4475629)	4475629..4476129	+	501	WP_004179811.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
MOO48_RS21480 (4476126)	4476126..4476452	+	327	WP_002904788.1	hydroxyisourate hydrolase	-
MOO48_RS21485 (4476718)	4476718..4476984	+	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
MOO48_RS21490 (4476984)	4476984..4478306	+	1323	WP_004179815.1	type II toxin-antitoxin system HipA family toxin	Toxin
MOO48_RS21495 (4478323)	4478323..4479615	-	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
MOO48_RS21500 (4479757)	4479757..4480761	-	1005	WP_004179822.1	fimbrial protein	-
MOO48_RS21505 (4480749)	4480749..4483250	-	2502	WP_004179823.1	fimbria/pilus outer membrane usher protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	blaSHV-28	iroE / rmpA / iutA / iucD / iucC / iucB / iucA	4376820..4815766	438946

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49152.42 Da
• Isoelectric Point: 7.2850

>T239328 WP_004179815.1 NZ_CP094227:4476984-4478306 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T239328 NZ_LR890679:c4799534-4799250 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT239328 WP_004176198.1 NZ_CP094227:4476718-4476984 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT239328 NZ_LR890679:c4799766-4799524 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA