Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2820403..2820919 Replicon chromosome
Accession NZ_CP094227
Organism Klebsiella pneumoniae strain Bio3

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag MOO48_RS13525 Protein ID WP_004178374.1
Coordinates 2820635..2820919 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag MOO48_RS13520 Protein ID WP_002886901.1
Coordinates 2820403..2820645 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOO48_RS13505 (2816431) 2816431..2817171 + 741 WP_002886899.1 KDGP aldolase family protein -
MOO48_RS13510 (2817238) 2817238..2818392 + 1155 WP_004178372.1 lactonase family protein -
MOO48_RS13515 (2818415) 2818415..2820325 + 1911 WP_004178373.1 PRD domain-containing protein -
MOO48_RS13520 (2820403) 2820403..2820645 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MOO48_RS13525 (2820635) 2820635..2820919 + 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MOO48_RS13530 (2820923) 2820923..2821387 - 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MOO48_RS13535 (2821628) 2821628..2823766 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
MOO48_RS13540 (2824123) 2824123..2824866 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
MOO48_RS13545 (2824869) 2824869..2825042 - 174 WP_032408826.1 hypothetical protein -
MOO48_RS13550 (2825172) 2825172..2825435 + 264 WP_228985702.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T239317 WP_004178374.1 NZ_CP094227:2820635-2820919 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T239317 NZ_LR890671:61866-62348 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT239317 WP_002886901.1 NZ_CP094227:2820403-2820645 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT239317 NZ_LR890671:61612-61878 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATTCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References