Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 582682..583306 Replicon chromosome
Accession NZ_CP094178
Organism Helicobacter pylori strain Hpfe060

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MPF93_RS02850 Protein ID WP_220923419.1
Coordinates 583040..583306 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MPF93_RS02845 Protein ID WP_245074413.1
Coordinates 582682..583053 (+) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPF93_RS02820 (MPF93_02820) 577777..578889 + 1113 WP_245074393.1 hydrogenase formation protein HypD -
MPF93_RS02825 (MPF93_02825) 578840..579454 - 615 WP_245074395.1 helicase DnaB modulator -
MPF93_RS02840 (MPF93_02840) 579833..582055 + 2223 WP_245074411.1 Hop family adhesin BabA -
MPF93_RS02845 (MPF93_02845) 582682..583053 + 372 WP_245074413.1 hypothetical protein Antitoxin
MPF93_RS02850 (MPF93_02850) 583040..583306 + 267 WP_220923419.1 type II toxin-antitoxin system YafQ family toxin Toxin
MPF93_RS02855 (MPF93_02855) 583414..583938 - 525 WP_001135611.1 acyl-CoA thioesterase -
MPF93_RS02860 (MPF93_02860) 584078..584920 + 843 WP_245074415.1 SDR family oxidoreductase -
MPF93_RS02865 (MPF93_02865) 584913..585893 + 981 WP_154501070.1 iron ABC transporter permease -
MPF93_RS02870 (MPF93_02870) 585893..586660 + 768 WP_017282092.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10394.39 Da        Isoelectric Point: 10.0434

>T239313 WP_220923419.1 NZ_CP094178:583040-583306 [Helicobacter pylori]
MLKIKHHILYKKDFKKLIKNGFDDSVLNEVILTLRKKEPLDPQFKDHALKGNWKPFRECHIKADILLVYLVKGDELILLR
LGSHSELF

Download         Length: 267 bp

>T239313 NZ_LR890669:c5012062-5011679 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGCCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 14442.37 Da        Isoelectric Point: 6.4177

>AT239313 WP_245074413.1 NZ_CP094178:582682-583053 [Helicobacter pylori]
MPNSSTKKDYTQYSEKQLFNLINQLEQKIKKMQNDRVSFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCL
GRKIPNLETQQAMRDALNGEKLETIEDLSAWANEVKKEVNAEN

Download         Length: 372 bp

>AT239313 NZ_LR890669:c5012304-5012062 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTAAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References