Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 17903..19091 Replicon chromosome
Accession NZ_CP094178
Organism Helicobacter pylori strain Hpfe060

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag MPF93_RS00075 Protein ID WP_245073768.1
Coordinates 18330..19091 (+) Length 254 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag MPF93_RS00070 Protein ID WP_096521412.1
Coordinates 17903..18340 (+) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPF93_RS00060 (MPF93_00060) 16356..16613 + 258 WP_245073764.1 hypothetical protein -
MPF93_RS00065 (MPF93_00065) 17054..17677 + 624 WP_245073766.1 hypothetical protein -
MPF93_RS00070 (MPF93_00070) 17903..18340 + 438 WP_096521412.1 Panacea domain-containing protein Antitoxin
MPF93_RS00075 (MPF93_00075) 18330..19091 + 762 WP_245073768.1 hypothetical protein Toxin
MPF93_RS00080 (MPF93_00080) 19320..20507 - 1188 WP_245073770.1 transcription termination factor NusA -
MPF93_RS00085 (MPF93_00085) 20595..21755 - 1161 WP_245073772.1 aminotransferase class V-fold PLP-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(24-119)


Sequences

Toxin        


Download         Length: 254 a.a.        Molecular weight: 29704.89 Da        Isoelectric Point: 9.4662

>T239312 WP_245073768.1 NZ_CP094178:18330-19091 [Helicobacter pylori]
METKEEDKDKKLEKIIVLLCEEGDLSSQKDQIIKDLKEIYKGEYKHKYSKITTIILNSTRDKEQAFMMLTQNIKTLKEIQ
DNKEVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKDISIRLDNLNKNYKKLSEELNKQQTQYITILGIFASIVLTFVG
GLAFSTSVLSNIDKANAYRLVFVMAFIALFFGNILYLLFSFLSKISLSKEKKDKQENFFKKPIFWFNLMVTILFVIGFVG
ELHIIQRLASKYF

Download         Length: 762 bp

>T239312 NZ_LR890669:c4692648-4691731 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTAGAAGGTGGCACTGCAATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAGTCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 17281.41 Da        Isoelectric Point: 6.2653

>AT239312 WP_096521412.1 NZ_CP094178:17903-18340 [Helicobacter pylori]
MVNALELAKYILKRSNKELSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWKYGPVAREVYYEYRNYGANSIDKPKEETL
SQNLRKDELETINYSIEKCNEKSYWDLVKESHKEDGAWHKSFKEDRKEVISKDLIKQEAKQANGN

Download         Length: 438 bp

>AT239312 NZ_LR890669:c4693412-4692654 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References