Detailed information of TA system TA239311

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 17959..19168
• Replicon: chromosome
• Accession: NZ_CP094177
• Organism: Helicobacter pylori strain Hpfe062

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: MPG60_RS00075
• Protein ID: WP_245084609.1
• Coordinates: 18386..19168 (+)
• Length: 261 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: MPG60_RS00070
• Protein ID: WP_140562945.1
• Coordinates: 17959..18396 (+)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPG60_RS00065 (MPG60_00065)	16112..17735	+	1624	Protein_10	RNA-directed DNA polymerase	-
MPG60_RS00070 (MPG60_00070)	17959..18396	+	438	WP_140562945.1	Panacea domain-containing protein	Antitoxin
MPG60_RS00075 (MPG60_00075)	18386..19168	+	783	WP_245084609.1	hypothetical protein	Toxin
MPG60_RS00080 (MPG60_00080)	19395..20582	-	1188	WP_245084612.1	transcription termination factor NusA	-
MPG60_RS00085 (MPG60_00085)	20670..21830	-	1161	WP_245084615.1	aminotransferase class V-fold PLP-dependent enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (24-119)

Sequences

Toxin

Protein

• Length: 261 a.a.
• Molecular weight: 30607.85 Da
• Isoelectric Point: 9.4532

>T239311 WP_245084609.1 NZ_CP094177:18386-19168 [Helicobacter pylori]
MEIKEEDKDKKLEKIIVLLCEEGDLSSQKDQIIKDLKEIYKGEYKHKYSKITTIILNSTRDKEQAFMMLTQNIKTLKEIQ
DNKEVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKNVSIKLEDELNKNYKKLSEELNKQQTQYITILGIFASIVLTFV
GGLAFSTSVLSNIDKANAYRLVFVMAFIALFFGNILYRLFSFLSKISLSEEKKDKQENFFKKLIFWFNLMVIILFVIGFV
GERIDGQYKAQISKDFKRPR

Nucleotide

• Length: 783 bp

>T239311 NZ_LR890669:c4538110-4537826 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCTGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 17300.37 Da
• Isoelectric Point: 5.7254

>AT239311 WP_140562945.1 NZ_CP094177:17959-18396 [Helicobacter pylori]
MVNTLELAKYILKHSNKELSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWKYGPVAREVYYEYRNYGANSIDKPKEETL
SQNLREDELETINRSIEKCNEKSYWDLVKESHKEDGAWHKSFKEDRKEIISKDLIKQEAKQANGN

Nucleotide

• Length: 438 bp

>AT239311 NZ_LR890669:c4538342-4538100 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA