Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 575903..576527 Replicon chromosome
Accession NZ_CP094175
Organism Helicobacter pylori strain Hpfe063

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MPG43_RS02785 Protein ID WP_245030997.1
Coordinates 576261..576527 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MPG43_RS02780 Protein ID WP_245030995.1
Coordinates 575903..576280 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPG43_RS02750 (MPG43_02750) 570904..571140 + 237 WP_000335476.1 HypC/HybG/HupF family hydrogenase formation chaperone -
MPG43_RS02755 (MPG43_02755) 571159..572271 + 1113 WP_245030989.1 hydrogenase formation protein HypD -
MPG43_RS02760 (MPG43_02760) 572222..572743 - 522 WP_245030991.1 hypothetical protein -
MPG43_RS02775 (MPG43_02775) 573265..575499 + 2235 WP_245030993.1 Hop family adhesin BabA -
MPG43_RS02780 (MPG43_02780) 575903..576280 + 378 WP_245030995.1 hypothetical protein Antitoxin
MPG43_RS02785 (MPG43_02785) 576261..576527 + 267 WP_245030997.1 type II toxin-antitoxin system YafQ family toxin Toxin
MPG43_RS02790 (MPG43_02790) 576611..577135 - 525 WP_001135615.1 hotdog domain-containing protein -
MPG43_RS02795 (MPG43_02795) 577274..578116 + 843 WP_180454877.1 SDR family oxidoreductase -
MPG43_RS02800 (MPG43_02800) 578109..579089 + 981 WP_000921438.1 iron ABC transporter permease -
MPG43_RS02805 (MPG43_02805) 579089..579856 + 768 WP_000242366.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10190.01 Da        Isoelectric Point: 9.6567

>T239310 WP_245030997.1 NZ_CP094175:576261-576527 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNAVILSLRKKEPLDPQFKDHALKGNWKPFRECHIKSDILLVYLVKGDELILVR
LGSHSELF

Download         Length: 267 bp

>T239310 NZ_LR890669:c4456123-4455590 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14661.52 Da        Isoelectric Point: 5.9643

>AT239310 WP_245030995.1 NZ_CP094175:575903-576280 [Helicobacter pylori]
MPNSPTKKDYTQYSEKQLFNLINQLEQKIKKMQNDRASFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDNKRDCCL
GHETPNLETQQAMRDALNKETDLIVEDFSSYSDERKKALGVETQP

Download         Length: 378 bp

>AT239310 NZ_LR890669:c4456400-4456134 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References