Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 20034..21240 Replicon chromosome
Accession NZ_CP094175
Organism Helicobacter pylori strain Hpfe063

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag MPG43_RS00080 Protein ID WP_245030474.1
Coordinates 20461..21240 (+) Length 260 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag MPG43_RS00075 Protein ID WP_128479173.1
Coordinates 20034..20471 (+) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPG43_RS00060 (MPG43_00060) 17119..17652 + 534 WP_245030470.1 TaqI-like C-terminal specificity domain-containing protein -
MPG43_RS00065 (MPG43_00065) 17653..18174 + 522 WP_245030472.1 hypothetical protein -
MPG43_RS00070 (MPG43_00070) 18185..19810 + 1626 WP_245031282.1 RNA-directed DNA polymerase -
MPG43_RS00075 (MPG43_00075) 20034..20471 + 438 WP_128479173.1 Panacea domain-containing protein Antitoxin
MPG43_RS00080 (MPG43_00080) 20461..21240 + 780 WP_245030474.1 hypothetical protein Toxin
MPG43_RS00085 (MPG43_00085) 21469..22656 - 1188 WP_245030476.1 transcription termination factor NusA -
MPG43_RS00090 (MPG43_00090) 22744..23904 - 1161 WP_245030477.1 aminotransferase class V-fold PLP-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(24-119)


Sequences

Toxin        


Download         Length: 260 a.a.        Molecular weight: 30378.56 Da        Isoelectric Point: 6.7319

>T239309 WP_245030474.1 NZ_CP094175:20461-21240 [Helicobacter pylori]
METKEEDKDKKLEEIIVLLCEEGDLSSQKDQIIKDLKEIYEGEYKHKYSKITTIILNSIRDKEQAFMMLTQNIKTLKEIQ
DNKEVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKDISIKLDNLNKNYKKLSEELNKQQTQYITILGIFVSIVLTFVG
GLAFSTSVLSNIDKANAYRLVFVMAFIALFFGNILYLLFSFLSKISLSSKISLSEEEKDKQENFFKKPIFWFNLMVTILF
VIGFFGELHIIQRLVSKYL

Download         Length: 780 bp

>T239309 NZ_LR890669:3832666-3832884 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 17246.32 Da        Isoelectric Point: 5.7254

>AT239309 WP_128479173.1 NZ_CP094175:20034-20471 [Helicobacter pylori]
MVNTLELAKYILKHSNKELSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWKYGPVAREVYYEYRNYGASSIDKPKEETL
SQSLREDELETINRSIEKCNEKSYWDLVKESHKEDGAWHKSFKEDRKEIISKDLIKQEAKQANGN

Download         Length: 438 bp

>AT239309 NZ_LR890669:3832265-3832639 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References