Detailed information of TA system TA239307

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 612877..613447
• Replicon: chromosome
• Accession: NZ_CP094173
• Organism: Helicobacter pylori strain Hpfe0001

Toxin (Protein)

• Gene name: relE
• Uniprot ID: T0EUM7
• Locus tag: MPG49_RS02980
• Protein ID: WP_021301977.1
• Coordinates: 613175..613447 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MPG49_RS02975
• Protein ID: WP_245052879.1
• Coordinates: 612877..613188 (+)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPG49_RS02950 (MPG49_02950)	608835..609485	-	651	Protein_564	helicase DnaB modulator	-
MPG49_RS02965 (MPG49_02965)	609861..612086	+	2226	WP_245052877.1	Hop family adhesin BabA	-
MPG49_RS02970 (MPG49_02970)	612462..612801	+	340	Protein_566	hypothetical protein	-
MPG49_RS02975 (MPG49_02975)	612877..613188	+	312	WP_245052879.1	type II toxin-antitoxin system antitoxin	Antitoxin
MPG49_RS02980 (MPG49_02980)	613175..613447	+	273	WP_021301977.1	type II toxin-antitoxin system mRNA interferase toxin, HP0892 family	Toxin
MPG49_RS02985 (MPG49_02985)	613555..614079	-	525	WP_220957869.1	acyl-CoA thioesterase	-
MPG49_RS02990 (MPG49_02990)	614220..615062	+	843	WP_245052881.1	SDR family oxidoreductase	-
MPG49_RS02995 (MPG49_02995)	615055..616035	+	981	WP_245052883.1	iron ABC transporter permease	-
MPG49_RS03000 (MPG49_03000)	616035..616802	+	768	WP_000242366.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10555.60 Da
• Isoelectric Point: 9.9378

>T239307 WP_021301977.1 NZ_CP094173:613175-613447 [Helicobacter pylori]
MLMIETSKKFDKDLKILVKNGFDLKLLYKVVENLAKEQPLAPKYKDHPLKGALKDFRECHLKPDLLLVYQIKKQENTLFL
VRLGSHSELF

Nucleotide

• Length: 273 bp

>T239307 NZ_LR890669:c2527128-2525806 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGAGGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCGCCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATAGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 12306.16 Da
• Isoelectric Point: 10.2819

>AT239307 WP_245052879.1 NZ_CP094173:612877-613188 [Helicobacter pylori]
MPNTTAKKDYTRYSEKQLFNFLNSIKTKQKRALEKLKEIQAQKQRIKKALQFKALHLTENGYTIEEEREILARAKDTKNH
LCFKSVEDFKKHCENLRFKNADD

Nucleotide

• Length: 312 bp

>AT239307 NZ_LR890669:c2527394-2527128 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Structures

Toxin

• AlphaFold DB: T0EUM7