239306

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 577788..578412 Replicon chromosome
Accession NZ_CP094172
Organism Helicobacter pylori strain Hpfe0002

Toxin (Protein)


Gene name relE Uniprot ID A0A1Q2PIC7
Locus tag MPG23_RS02755 Protein ID WP_000916176.1
Coordinates 578146..578412 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MPG23_RS02750 Protein ID WP_245089331.1
Coordinates 577788..578165 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPG23_RS02720 (MPG23_02720) 572864..573100 + 237 WP_219025537.1 HypC/HybG/HupF family hydrogenase formation chaperone -
MPG23_RS02725 (MPG23_02725) 573128..574240 + 1113 WP_245089314.1 hydrogenase formation protein HypD -
MPG23_RS02730 (MPG23_02730) 574191..574841 - 651 Protein_521 helicase DnaB modulator -
MPG23_RS02745 (MPG23_02745) 575218..577443 + 2226 WP_245089327.1 Hop family adhesin BabA -
MPG23_RS02750 (MPG23_02750) 577788..578165 + 378 WP_245089331.1 hypothetical protein Antitoxin
MPG23_RS02755 (MPG23_02755) 578146..578412 + 267 WP_000916176.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
MPG23_RS02760 (MPG23_02760) 578515..579039 - 525 WP_053460345.1 acyl-CoA thioesterase -
MPG23_RS02765 (MPG23_02765) 579180..580022 + 843 WP_245089334.1 SDR family oxidoreductase -
MPG23_RS02770 (MPG23_02770) 580015..580995 + 981 WP_000921452.1 iron ABC transporter permease -
MPG23_RS02775 (MPG23_02775) 580995..581762 + 768 WP_000242365.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10245.13 Da        Isoelectric Point: 9.9517

>T239306 WP_000916176.1 NZ_CP094172:578146-578412 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNKVILSLRKKEPLDPQFQDHALKGKWKPFRECHIKADILLVYLVKGDELILVR
LGSHSELF

Download         Length: 267 bp

>T239306 NZ_LR890669:1832595-1832697 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14798.84 Da        Isoelectric Point: 9.0129

>AT239306 WP_245089331.1 NZ_CP094172:577788-578165 [Helicobacter pylori]
MPNSPTKKDYTQYSEKQLFNLIHQLERKIKKMQNDRVSFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCL
GRKIPNIQTQQAMRDALNKETDLIVEDFSSYSDERKRALGVETQP

Download         Length: 378 bp

>AT239306 NZ_LR890669:c1832704-1832559 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q2PIC7

Antitoxin

Source ID Structure

References