Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 17692..18883 Replicon chromosome
Accession NZ_CP094171
Organism Helicobacter pylori strain Hpfe0003

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag MPG20_RS00075 Protein ID WP_245074255.1
Coordinates 18119..18883 (+) Length 255 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag MPG20_RS00070 Protein ID WP_245074253.1
Coordinates 17692..18129 (+) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPG20_RS00065 (MPG20_00065) 15913..17466 + 1554 WP_245074251.1 RNA-directed DNA polymerase -
MPG20_RS00070 (MPG20_00070) 17692..18129 + 438 WP_245074253.1 Panacea domain-containing protein Antitoxin
MPG20_RS00075 (MPG20_00075) 18119..18883 + 765 WP_245074255.1 hypothetical protein Toxin
MPG20_RS00080 (MPG20_00080) 19112..20299 - 1188 WP_245074257.1 transcription termination factor NusA -
MPG20_RS00085 (MPG20_00085) 20387..21547 - 1161 WP_245074259.1 aminotransferase class V-fold PLP-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(24-119)


Sequences

Toxin        


Download         Length: 255 a.a.        Molecular weight: 29864.97 Da        Isoelectric Point: 7.8438

>T239304 WP_245074255.1 NZ_CP094171:18119-18883 [Helicobacter pylori]
METKEEDKDKKLEKIIVLLCEEGDLSSQKDQIIKDLKEIYEGEYKHKYSKITTIILNSTRDKEQAFMMLTQNIKTLKEIQ
DNKEVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKDVSIRLEDDLNKNYKKLSEELNKQQTQYITILGIFASIVLTFV
GGLAFSTSVLSNIDKANAYRLVFVMAFIALFFGNILYLLFSFLSKISLSKEKKDKEENFFKKPIFWFNLMVTILFVIGFF
GELHIIQRLVSKYL

Download         Length: 765 bp

>T239304 NZ_LR890669:714310-714795 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGACCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCGCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATTCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 17288.45 Da        Isoelectric Point: 6.7308

>AT239304 WP_245074253.1 NZ_CP094171:17692-18129 [Helicobacter pylori]
MVNALELAKYILKRSNKELSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWKYGPVAREVYYEYRNYGANSIDKPKEETL
SQNLRKDELETINRSIEKCNEKSYWDLVKESHKEDGAWHKSFKEDRKEIISKDLIKQEAKQANGN

Download         Length: 438 bp

>AT239304 NZ_LR890669:714020-714313 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References