Detailed information of TA system TA239303

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 569961..570531
• Replicon: chromosome
• Accession: NZ_CP094168
• Organism: Helicobacter pylori strain Hpfe0006

Toxin (Protein)

• Gene name: relE
• Uniprot ID: D0K031
• Locus tag: MPG70_RS02760
• Protein ID: WP_000928609.1
• Coordinates: 570259..570531 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MPG70_RS02755
• Protein ID: WP_212893630.1
• Coordinates: 569961..570272 (+)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPG70_RS02730 (MPG70_02730)	565918..566564	-	647	Protein_520	helicase DnaB modulator	-
MPG70_RS02745 (MPG70_02745)	566954..569188	+	2235	WP_245062654.1	Hop family adhesin BabA	-
MPG70_RS02750 (MPG70_02750)	569545..569901	+	357	WP_245062656.1	hypothetical protein	-
MPG70_RS02755 (MPG70_02755)	569961..570272	+	312	WP_212893630.1	type II toxin-antitoxin system antitoxin	Antitoxin
MPG70_RS02760 (MPG70_02760)	570259..570531	+	273	WP_000928609.1	type II toxin-antitoxin system mRNA interferase toxin, HP0892 family	Toxin
MPG70_RS02765 (MPG70_02765)	570635..571159	-	525	WP_001135610.1	acyl-CoA thioesterase	-
MPG70_RS02770 (MPG70_02770)	571299..572141	+	843	WP_245062658.1	SDR family oxidoreductase	-
MPG70_RS02775 (MPG70_02775)	572134..573114	+	981	WP_245062660.1	iron ABC transporter permease	-
MPG70_RS02780 (MPG70_02780)	573114..573881	+	768	WP_245062662.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10599.61 Da
• Isoelectric Point: 9.7265

>T239303 WP_000928609.1 NZ_CP094168:570259-570531 [Helicobacter pylori]
MLMIETSKKFDKDLKILVKNGFDLKLLYKVVENLAKEQPLDPKYKDHPLKGALKDFRECHLKPDLLLVYQIKKQENTLFL
VRLGSHSELF

Nucleotide

• Length: 273 bp

>T239303 NZ_LR890669:350324-350671 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGATTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCAGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 12343.22 Da
• Isoelectric Point: 10.1678

>AT239303 WP_212893630.1 NZ_CP094168:569961-570272 [Helicobacter pylori]
MPNSPIKKDYTQYSEKQLFNFLNSIKTKQKRALEKLKEIQAQKQRIKKALQFKALHLTENGYTIEEEREILARAKDTKNH
LCFKNIEDFKKHCENLRFKNADD

Nucleotide

• Length: 312 bp

>AT239303 NZ_LR890669:350671-350970 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGAGACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGACTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Structures

Toxin

• AlphaFold DB: A0A0L0P915