239302

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 576456..577080 Replicon chromosome
Accession NZ_CP094167
Organism Helicobacter pylori strain Hpfe0007

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MPG42_RS02770 Protein ID WP_140497734.1
Coordinates 576814..577080 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MPG42_RS02765 Protein ID WP_245028829.1
Coordinates 576456..576833 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPG42_RS02735 (MPG42_02735) 571465..571701 + 237 WP_180428319.1 HypC/HybG/HupF family hydrogenase formation chaperone -
MPG42_RS02740 (MPG42_02740) 571729..572841 + 1113 WP_245028825.1 hydrogenase formation protein HypD -
MPG42_RS02745 (MPG42_02745) 572792..573445 - 654 Protein_524 helicase DnaB modulator -
MPG42_RS02760 (MPG42_02760) 573838..576069 + 2232 WP_245028827.1 Hop family adhesin BabA -
MPG42_RS02765 (MPG42_02765) 576456..576833 + 378 WP_245028829.1 hypothetical protein Antitoxin
MPG42_RS02770 (MPG42_02770) 576814..577080 + 267 WP_140497734.1 type II toxin-antitoxin system YafQ family toxin Toxin
MPG42_RS02775 (MPG42_02775) 577177..577701 - 525 WP_058060478.1 acyl-CoA thioesterase -
MPG42_RS02780 (MPG42_02780) 577842..578684 + 843 WP_245028831.1 SDR family oxidoreductase -
MPG42_RS02785 (MPG42_02785) 578677..579657 + 981 WP_000921438.1 iron ABC transporter permease -
MPG42_RS02790 (MPG42_02790) 579657..580424 + 768 WP_121018883.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10318.18 Da        Isoelectric Point: 9.0027

>T239302 WP_140497734.1 NZ_CP094167:576814-577080 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNEVILTLRKKEPLDPQFKDHALKGKWKPFRECHIKADILLVYLVKDDELILVR
LGSHSELF

Download         Length: 267 bp

>T239302 NZ_LR890669:324356-324724 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGCGGATGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14641.58 Da        Isoelectric Point: 8.4576

>AT239302 WP_245028829.1 NZ_CP094167:576456-576833 [Helicobacter pylori]
MPNSSAKKDYTQYSEKQLFNLINQLEQKIKKMQNDRVSFKEKMAKELDKRDQNFKDKIDALNELLQKISQAFDNKRDCCL
GRKIPNLETQQAMRDALNKETDLIVDDFSSYSDERKKALGVETQS

Download         Length: 378 bp

>AT239302 NZ_LR890669:324138-324359 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References