Detailed information of TA system TA239298

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 617105..617729
• Replicon: chromosome
• Accession: NZ_CP094163
• Organism: Helicobacter pylori strain Hpfe0013

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A2A6UH71
• Locus tag: MPG54_RS02960
• Protein ID: WP_025455067.1
• Coordinates: 617463..617729 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MPG54_RS02955
• Protein ID: WP_245041313.1
• Coordinates: 617105..617482 (+)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPG54_RS02930 (MPG54_02930)	612217..613329	+	1113	WP_245041311.1	hydrogenase formation protein HypD	-
MPG54_RS02935 (MPG54_02935)	613280..613923	-	644	Protein_562	helicase DnaB modulator	-
MPG54_RS02950 (MPG54_02950)	614292..616526	+	2235	WP_245041312.1	Hop family adhesin BabA	-
MPG54_RS02955 (MPG54_02955)	617105..617482	+	378	WP_245041313.1	hypothetical protein	Antitoxin
MPG54_RS02960 (MPG54_02960)	617463..617729	+	267	WP_025455067.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
MPG54_RS02965 (MPG54_02965)	617815..618339	-	525	WP_001135602.1	acyl-CoA thioesterase	-
MPG54_RS02970 (MPG54_02970)	618479..619321	+	843	WP_245041314.1	SDR family oxidoreductase	-
MPG54_RS02975 (MPG54_02975)	619314..620294	+	981	WP_000921438.1	iron ABC transporter permease	-
MPG54_RS02980 (MPG54_02980)	620294..621061	+	768	WP_000242365.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10303.17 Da
• Isoelectric Point: 9.6292

>T239298 WP_025455067.1 NZ_CP094163:617463-617729 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNKVILSLRKKEPLDPQFQDHALKGKWKPFRECHIKADILLVYLVKDDELILVR
LGSHSELF

Nucleotide

• Length: 267 bp

>T239298 NZ_LR890666:c177254-176838 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTACGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGATGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGCGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCAGCCGGCGCCGTCCTGGTGACGAACAATGTGCGGGAGTTTGAGCGGGTGCCGGGCCTGATGCTGG
AAGACTGGGTGAATTAA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 14714.76 Da
• Isoelectric Point: 8.9977

>AT239298 WP_245041313.1 NZ_CP094163:617105-617482 [Helicobacter pylori]
MPNSPTKKDYTQYSEKQLFNLIHQLEQKIKKMQNDRASFKEKMAKELEKRDQNFKDKIDALNKLLQKISQAFDDKRDCCL
GRKIPNLETQQAMRDALNKETDLIVEDFSSYSDERKKALGVETQP

Nucleotide

• Length: 378 bp

>AT239298 NZ_LR890666:c177481-177251 [Klebsiella pneumoniae]
ATGAGAACCGTATCTATTTTTAAAAACGGCAACAACCGCGCCATCCGCCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGTCCCGTCCGGCCGACATGGGGCTCGTTCGCGCAACTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGCGCCATGA

Structures

Toxin

• AlphaFold DB: A0A2A6UH71