Detailed information of TA system TA239296

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 1095070..1095688
• Replicon: chromosome
• Accession: NZ_CP094160
• Organism: Helicobacter pylori strain Hpfe0016

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MPG03_RS05275
• Protein ID: WP_120866920.1
• Coordinates: 1095070..1095330 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MPG03_RS05280
• Protein ID: WP_245020984.1
• Coordinates: 1095311..1095688 (-)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPG03_RS05255 (MPG03_05255)	1091737..1092504	-	768	WP_000242366.1	ABC transporter ATP-binding protein	-
MPG03_RS05260 (MPG03_05260)	1092504..1093484	-	981	WP_000921452.1	iron ABC transporter permease	-
MPG03_RS05265 (MPG03_05265)	1093477..1094319	-	843	WP_245020982.1	SDR family oxidoreductase	-
MPG03_RS05270 (MPG03_05270)	1094462..1094986	+	525	WP_245020983.1	acyl-CoA thioesterase	-
MPG03_RS05275 (MPG03_05275)	1095070..1095330	-	261	WP_120866920.1	type II toxin-antitoxin system YafQ family toxin	Toxin
MPG03_RS05280 (MPG03_05280)	1095311..1095688	-	378	WP_245020984.1	hypothetical protein	Antitoxin
MPG03_RS05285 (MPG03_05285)	1096238..1098472	-	2235	WP_245020985.1	Hop family adhesin BabA	-
MPG03_RS05300 (MPG03_05300)	1098983..1099504	+	522	WP_245020986.1	hypothetical protein	-
MPG03_RS05305 (MPG03_05305)	1099455..1100567	-	1113	WP_245020987.1	hydrogenase formation protein HypD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10117.95 Da
• Isoelectric Point: 9.0027

>T239296 WP_120866920.1 NZ_CP094160:c1095330-1095070 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNEVILRKKEPLDPQFKDHALKGKWKPFRECHIKADILLVYLVKDDELILLRLG
SHSELF

Nucleotide

• Length: 261 bp

>T239296 NZ_LR890666:22660-23142 [Klebsiella pneumoniae]
ATGGGACTGAGGCCTCCGGAACCTCTTACCCCTGAACACAACATTGCTGAGTTTTGTTGTCAGGATCAGGTTCTTTCTGA
GTGGTTGAAGAAAAAGGCGCTGAAGAACCACAGAACGGGCATTTCAAGAGTTTTCGTCGTCTGTGCTGAAAACACGAATA
GGGTAATTGCGTACTACTGTTTGGCATCCGGAAGCGTGCACAGAAACACCGTACCTGGAGCATACCGTCGTAATGCACCA
GAGGCTTTACCGGTCATTGTTCTGGGAAGGCTTGCGGTTGACGCTGCCTGGGCAAGAAAAGGGCTGGGAGCTGCGCTGCT
TAAGGATGCGATATACCGAACAGAACATATTGCAATACAGGTTGGTGTTAGGGCGCTTCTTGTTCACGCCTTAAATGATG
AAGTTAGGGAATTTTACACAAAGTTTGGATTCGAGCCCTCCATTGCCAATGCGCTGACATTATTATTTCCGATCAAAACA
TGA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 14674.66 Da
• Isoelectric Point: 9.4274

>AT239296 WP_245020984.1 NZ_CP094160:c1095688-1095311 [Helicobacter pylori]
MPNSPTKKDYTQYSEKQLFNLIHQLEQKIKRMQNDRASFKEKMAKELDKRDQNFKDKIDALNGLLQKISQAFDDKRDCCL
GRKIPNLETQQAMRDALNKETDLIVEDFSSYSDERKRALGVKTQS

Nucleotide

• Length: 378 bp

>AT239296 NZ_LR890666:22391-22669 [Klebsiella pneumoniae]
ATGAAACCAGACATTCGTGAGGCTCCGATAAACATCCGGGCGAAAACATCTCAACGCGATCTTATCGACATGGCCGCAAA
TCTTGTATCTAAATCACGTACTGATTTTATGCTGGAAGTGGCCTGCCGCGAAGCGCAGGACATCTTGTTAGATCAGCGCT
TGTTTCTGCTGGATGATAATCAGTTTAACGCGTTTGTCGAAGAGCTTGACGCCCCTATGACCCCAGAGCGTCAGGCGCGT
ATTGATAACCTGATGAGCCGCAAATCGCCATGGGACTGA