Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 1083477..1084047 Replicon chromosome
Accession NZ_CP094157
Organism Helicobacter pylori strain Hpfe0021

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MPG52_RS05080 Protein ID WP_245076315.1
Coordinates 1083477..1083749 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MPG52_RS05085 Protein ID WP_245076317.1
Coordinates 1083736..1084047 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPG52_RS05060 (MPG52_05060) 1080129..1080896 - 768 WP_015644163.1 ABC transporter ATP-binding protein -
MPG52_RS05065 (MPG52_05065) 1080896..1081876 - 981 WP_000921461.1 iron ABC transporter permease -
MPG52_RS05070 (MPG52_05070) 1081869..1082723 - 855 WP_245076313.1 SDR family oxidoreductase -
MPG52_RS05075 (MPG52_05075) 1082863..1083387 + 525 WP_001135623.1 acyl-CoA thioesterase -
MPG52_RS05080 (MPG52_05080) 1083477..1083749 - 273 WP_245076315.1 type II toxin-antitoxin system mRNA interferase toxin, HP0892 family Toxin
MPG52_RS05085 (MPG52_05085) 1083736..1084047 - 312 WP_245076317.1 type II toxin-antitoxin system antitoxin Antitoxin
MPG52_RS05090 (MPG52_05090) 1084382..1086598 - 2217 WP_245076319.1 Hop family adhesin BabA -
MPG52_RS05105 (MPG52_05105) 1086984..1087626 + 643 Protein_1004 helicase DnaB modulator -
MPG52_RS05110 (MPG52_05110) 1087577..1088689 - 1113 WP_245076321.1 hydrogenase formation protein HypD -
MPG52_RS05115 (MPG52_05115) 1088707..1088943 - 237 WP_000335444.1 HypC/HybG/HupF family hydrogenase formation chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10569.52 Da        Isoelectric Point: 9.7265

>T239295 WP_245076315.1 NZ_CP094157:c1083749-1083477 [Helicobacter pylori]
MLTIETSKKFDKDLKILVKNGFDLKLLYKVVENLAKEQPLEPKYKDHPLKGGLKDFRECHLKPDLLLVYQIKKQENTLFL
VRLGSHSELF

Download         Length: 273 bp

>T239295 NZ_LR890665:c5240386-5240003 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCATCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 12304.05 Da        Isoelectric Point: 9.4291

>AT239295 WP_245076317.1 NZ_CP094157:c1084047-1083736 [Helicobacter pylori]
MPNTTAEKDYTKYSEKQLVNFLNSIKTKQKRALEKLKEIQAQKQRIKKALQFKALHLTENGYTIEEEREILERAEDTKNH
LCFKSIEDFKKHCENLRFKNADD

Download         Length: 312 bp

>AT239295 NZ_LR890665:c5240628-5240386 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References