Detailed information of TA system TA239293

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 18426..19617
• Replicon: chromosome
• Accession: NZ_CP094157
• Organism: Helicobacter pylori strain Hpfe0021

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: MPG52_RS00065
• Protein ID: WP_120919278.1
• Coordinates: 18853..19617 (+)
• Length: 255 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: MPG52_RS00060
• Protein ID: WP_120919276.1
• Coordinates: 18426..18863 (+)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPG52_RS00055 (MPG52_00055)	14171..17926	+	3756	WP_245076690.1	class I SAM-dependent DNA methyltransferase	-
MPG52_RS00060 (MPG52_00060)	18426..18863	+	438	WP_120919276.1	Panacea domain-containing protein	Antitoxin
MPG52_RS00065 (MPG52_00065)	18853..19617	+	765	WP_120919278.1	hypothetical protein	Toxin
MPG52_RS00070 (MPG52_00070)	19845..21032	-	1188	WP_245076691.1	transcription termination factor NusA	-
MPG52_RS00075 (MPG52_00075)	21120..22292	-	1173	WP_245076692.1	aminotransferase class V-fold PLP-dependent enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (24-119)

Sequences

Toxin

Protein

• Length: 255 a.a.
• Molecular weight: 29793.79 Da
• Isoelectric Point: 8.3856

>T239293 WP_120919278.1 NZ_CP094157:18853-19617 [Helicobacter pylori]
METKEEDKDKKLEEMIVSLCEKGDLSSQTDQIIKDLKEIYQGEYRHKYSKITTIILNSTRDREQAFMTLTQNIRTLKEIQ
DNKEVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKDVSIKLEDDLNKNYKKLSEELNKQQTQYITILGIFASIVLTFV
GGLAFSTSVLSNIDKANAYRLVFVMAFMALFFGNILYLLFSFLSKISLSKEKKDKQENFFKKPIFWFNLMVAILFVIGFV
GELHIIQRLVSKYL

Nucleotide

• Length: 765 bp

>T239293 NZ_LR890665:c4757224-4756940 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 17312.48 Da
• Isoelectric Point: 7.3523

>AT239293 WP_120919276.1 NZ_CP094157:18426-18863 [Helicobacter pylori]
MVNALELAKYILKHSNKELSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWKYGPVAREVYYEYRNYGANSIDKPKEESL
SQNLRKDELETINRSIEKCNKKSYWDLVKESHKEDGAWHKSFKEDRKEIISKDLIRQEAKQTNGN

Nucleotide

• Length: 438 bp

>AT239293 NZ_LR890665:c4757456-4757214 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCTGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA