Detailed information of TA system TA239292

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 611496..612066
• Replicon: chromosome
• Accession: NZ_CP094156
• Organism: Helicobacter pylori strain Hpfe005

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MPG67_RS02995
• Protein ID: WP_180475647.1
• Coordinates: 611794..612066 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0M0MSJ1
• Locus tag: MPG67_RS02990
• Protein ID: WP_001133857.1
• Coordinates: 611496..611807 (+)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPG67_RS02965 (MPG67_02965)	606618..607730	+	1113	WP_245073171.1	hydrogenase formation protein HypD	-
MPG67_RS02970 (MPG67_02970)	607681..608334	-	654	Protein_567	helicase DnaB modulator	-
MPG67_RS02985 (MPG67_02985)	608695..610920	+	2226	WP_245073173.1	Hop family adhesin BabA	-
MPG67_RS02990 (MPG67_02990)	611496..611807	+	312	WP_001133857.1	type II toxin-antitoxin system antitoxin	Antitoxin
MPG67_RS02995 (MPG67_02995)	611794..612066	+	273	WP_180475647.1	type II toxin-antitoxin system YafQ family toxin	Toxin
MPG67_RS03000 (MPG67_03000)	612174..612698	-	525	WP_001135615.1	hotdog domain-containing protein	-
MPG67_RS03005 (MPG67_03005)	612838..613686	+	849	WP_245073175.1	SDR family oxidoreductase	-
MPG67_RS03010 (MPG67_03010)	613679..614659	+	981	WP_245073177.1	iron ABC transporter permease	-
MPG67_RS03015 (MPG67_03015)	614659..615426	+	768	WP_000242363.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (4-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10599.61 Da
• Isoelectric Point: 9.7265

>T239292 WP_180475647.1 NZ_CP094156:611794-612066 [Helicobacter pylori]
MLMIETSKKFDKDLKILVKNGFDLKLLYKVVENLAKEQPLDPKYKDHPLKGALKDFRECHIKPDILLVYQIKKQENTLFL
VRLGSHSELF

Nucleotide

• Length: 273 bp

>T239292 NZ_LR890665:c4655149-4654616 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 12331.16 Da
• Isoelectric Point: 10.1678

>AT239292 WP_001133857.1 NZ_CP094156:611496-611807 [Helicobacter pylori]
MPNSPTKKDYTQYSEKQLFNFLNSIKTKQKRALEKLKEIQAQKQRIKKALQFKALHLTENGYTIEEEREILARAKDTKNH
LCFKNIEDFKKHCENLRFKNADD

Nucleotide

• Length: 312 bp

>AT239292 NZ_LR890665:c4655426-4655160 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0M0MSJ1