Detailed information of TA system TA239291

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): VapD-relB/-
• Location: 606404..607061
• Replicon: chromosome
• Accession: NZ_CP094153
• Organism: Helicobacter pylori strain Hpfe010

Toxin (Protein)

• Gene name: VapD
• Uniprot ID: T5D7N9
• Locus tag: MPF98_RS02935
• Protein ID: WP_000271050.1
• Coordinates: 606777..607061 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MPF98_RS02930
• Protein ID: WP_245049888.1
• Coordinates: 606404..606796 (+)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPF98_RS02910 (MPF98_02910)	602206..602727	-	522	WP_245049878.1	hypothetical protein	-
MPF98_RS02925 (MPF98_02925)	603252..605477	+	2226	WP_245049886.1	Hop family adhesin BabA	-
MPF98_RS02930 (MPF98_02930)	606404..606796	+	393	WP_245049888.1	hypothetical protein	Antitoxin
MPF98_RS02935 (MPF98_02935)	606777..607061	+	285	WP_000271050.1	endoribonuclease VapD	Toxin
MPF98_RS02940 (MPF98_02940)	607257..607781	-	525	WP_120845779.1	acyl-CoA thioesterase	-
MPF98_RS02945 (MPF98_02945)	607921..608769	+	849	WP_245049890.1	SDR family oxidoreductase	-
MPF98_RS02950 (MPF98_02950)	608762..609742	+	981	WP_000921438.1	iron ABC transporter permease	-
MPF98_RS02955 (MPF98_02955)	609742..610509	+	768	WP_120824486.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Virulence-associated protein D / CRISPR associated protein Cas2 (1-87)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11188.74 Da
• Isoelectric Point: 4.8896

>T239291 WP_000271050.1 NZ_CP094153:606777-607061 [Helicobacter pylori]
MYALAFDLKIEILKKEYGEPYNKAYDDLRQELELLGFEWTQGSVYVNYSKENTLAQVYKAINKLSQIEWFKKSVRDIRAF
KVEDFSDFTEIVKS

Nucleotide

• Length: 285 bp

>T239291 NZ_LR890665:4038414-4038632 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 15092.20 Da
• Isoelectric Point: 8.4847

>AT239291 WP_245049888.1 NZ_CP094153:606404-606796 [Helicobacter pylori]
MPNSPTKKDYTRYNEKQLFNLINQLEQKIKKMQNDRASFKEKMAKELEKRDQNFKDKIDALNGLLQKISQAFDNKRDCCL
GCKIPNLETQQAMRDALNGVNLTQIDSLDDLTNELKRENGKGFENVCFSV

Nucleotide

• Length: 393 bp

>AT239291 NZ_LR890665:4038013-4038387 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Structures

Toxin

• PDB: 3UI3