Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 18045..19224 Replicon chromosome
Accession NZ_CP094153
Organism Helicobacter pylori strain Hpfe010

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag MPF98_RS00085 Protein ID WP_245049310.1
Coordinates 18472..19224 (+) Length 251 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag MPF98_RS00080 Protein ID WP_024948607.1
Coordinates 18045..18482 (+) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPF98_RS00060 (MPF98_00060) 15651..16184 + 534 WP_245049302.1 hypothetical protein -
MPF98_RS00065 (MPF98_00065) 16201..16893 + 693 WP_245049304.1 hypothetical protein -
MPF98_RS00070 (MPF98_00070) 16901..17140 + 240 WP_245049306.1 RNA-directed DNA polymerase -
MPF98_RS00075 (MPF98_00075) 17168..17821 + 654 WP_245049308.1 hypothetical protein -
MPF98_RS00080 (MPF98_00080) 18045..18482 + 438 WP_024948607.1 Panacea domain-containing protein Antitoxin
MPF98_RS00085 (MPF98_00085) 18472..19224 + 753 WP_245049310.1 hypothetical protein Toxin
MPF98_RS00090 (MPF98_00090) 19451..20638 - 1188 WP_245049312.1 transcription termination factor NusA -
MPF98_RS00095 (MPF98_00095) 20726..21886 - 1161 WP_245049314.1 aminotransferase class V-fold PLP-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(24-119)


Sequences

Toxin        


Download         Length: 251 a.a.        Molecular weight: 29451.55 Da        Isoelectric Point: 9.4721

>T239289 WP_245049310.1 NZ_CP094153:18472-19224 [Helicobacter pylori]
MEIKEEDKDKKLEKIIVLLCEEGDLSSQKDQIIKDLKEIYKGEYKHKYSKITTIILNSTRDKEQAFMMLTQNIKTLKEIQ
DNKEVESIKPKLEKLYDHMNLECIRLQDFDEKMNYKKLSEELNKQQTQYITILGIFASIVLTFVGGLAFSTSVLSNIDKA
NAYRLVFIMAFIALFFGNILYLLFSFLSKISLSSKISLSKEERDKQENFFKKPIFWFNLMVIILFVIGFVGERIDRQYKA
QISKDFKRPR

Download         Length: 753 bp

>T239289 NZ_LR890665:1876866-1876968 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 17317.36 Da        Isoelectric Point: 5.3873

>AT239289 WP_024948607.1 NZ_CP094153:18045-18482 [Helicobacter pylori]
MVNTLELAKYILKHSNKELSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWKYGPVSREVYYEYRNYGANSIDKPKEETL
SQDLREDELETINRSIEKCNEKSYWDLVKESHKEDGAWHKSFKEDRKEIISKDLIKQEAKQANGN

Download         Length: 438 bp

>AT239289 NZ_LR890665:c1876975-1876830 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References