Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 579015..579639 Replicon chromosome
Accession NZ_CP094151
Organism Helicobacter pylori strain Hpfe019

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MPG81_RS02795 Protein ID WP_245087918.1
Coordinates 579373..579639 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MPG81_RS02790 Protein ID WP_245087915.1
Coordinates 579015..579392 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPG81_RS02765 (MPG81_02765) 574195..575307 + 1113 WP_245087908.1 hydrogenase formation protein HypD -
MPG81_RS02770 (MPG81_02770) 575258..575900 - 643 Protein_528 helicase DnaB modulator -
MPG81_RS02785 (MPG81_02785) 576273..578507 + 2235 WP_245087911.1 Hop family adhesin BabA -
MPG81_RS02790 (MPG81_02790) 579015..579392 + 378 WP_245087915.1 hypothetical protein Antitoxin
MPG81_RS02795 (MPG81_02795) 579373..579639 + 267 WP_245087918.1 type II toxin-antitoxin system YafQ family toxin Toxin
MPG81_RS02800 (MPG81_02800) 579717..580027 + 311 Protein_532 type II toxin-antitoxin system antitoxin -
MPG81_RS02805 (MPG81_02805) 580014..580286 + 273 WP_245087920.1 type II toxin-antitoxin system YafQ family toxin -
MPG81_RS02810 (MPG81_02810) 580392..580916 - 525 WP_212788721.1 acyl-CoA thioesterase -
MPG81_RS02815 (MPG81_02815) 581056..581904 + 849 WP_245087923.1 SDR family oxidoreductase -
MPG81_RS02820 (MPG81_02820) 581897..582877 + 981 WP_245087926.1 iron ABC transporter permease -
MPG81_RS02825 (MPG81_02825) 582877..583644 + 768 WP_245087930.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10364.19 Da        Isoelectric Point: 9.5173

>T239287 WP_245087918.1 NZ_CP094151:579373-579639 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNEVILTLRKKEPLSPQFQDHALKGKWKPFREYHIKADILLVYLVKDDELILLR
LGSHSELF

Download         Length: 267 bp

>T239287 NZ_LR890665:362243-362590 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGATTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14700.69 Da        Isoelectric Point: 9.4015

>AT239287 WP_245087915.1 NZ_CP094151:579015-579392 [Helicobacter pylori]
MPNSPTKKDYTQYSEKQLFNLINQLEQKIKKMQNDRASFKEKMAKELDKRDQNFKDKIDALNEFLQKISQAFDNKRDCCL
GRKIPNLETQQAMRDALNKETDLIVEDFSSYSDERKKALGVKTQS

Download         Length: 378 bp

>AT239287 NZ_LR890665:362590-362889 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References