Detailed information of TA system TA239285

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 614919..615489
• Replicon: chromosome
• Accession: NZ_CP094149
• Organism: Helicobacter pylori strain Hpfe023

Toxin (Protein)

• Gene name: relE
• Uniprot ID: T0EUM7
• Locus tag: MPF84_RS02960
• Protein ID: WP_021301977.1
• Coordinates: 615217..615489 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MPF84_RS02955
• Protein ID: WP_245052879.1
• Coordinates: 614919..615230 (+)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPF84_RS02930 (MPF84_02930)	610824..611467	-	644	Protein_561	helicase DnaB modulator	-
MPF84_RS02945 (MPF84_02945)	611840..614065	+	2226	WP_245086426.1	Hop family adhesin BabA	-
MPF84_RS02950 (MPF84_02950)	614504..614843	+	340	Protein_563	hypothetical protein	-
MPF84_RS02955 (MPF84_02955)	614919..615230	+	312	WP_245052879.1	type II toxin-antitoxin system antitoxin	Antitoxin
MPF84_RS02960 (MPF84_02960)	615217..615489	+	273	WP_021301977.1	type II toxin-antitoxin system mRNA interferase toxin, HP0892 family	Toxin
MPF84_RS02965 (MPF84_02965)	615597..616121	-	525	WP_220957869.1	acyl-CoA thioesterase	-
MPF84_RS02970 (MPF84_02970)	616262..617104	+	843	WP_245086429.1	SDR family oxidoreductase	-
MPF84_RS02975 (MPF84_02975)	617097..618077	+	981	WP_000921482.1	iron ABC transporter permease	-
MPF84_RS02980 (MPF84_02980)	618077..618844	+	768	WP_245086432.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10555.60 Da
• Isoelectric Point: 9.9378

>T239285 WP_021301977.1 NZ_CP094149:615217-615489 [Helicobacter pylori]
MLMIETSKKFDKDLKILVKNGFDLKLLYKVVENLAKEQPLAPKYKDHPLKGALKDFRECHLKPDLLLVYQIKKQENTLFL
VRLGSHSELF

Nucleotide

• Length: 273 bp

>T239285 NZ_LR890665:206677-207162 [Klebsiella pneumoniae]
GTGGGACGTATAACCGCGCCCGAGCCCTTATCCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCGCGGAAAAGGGCTTGGCGCTGATTT
ACTTCATGATGCAGTACTTCGTTGCTATCGGGTTGCCGAGAATATAGGTGTACGTGCAATCATGGTTCATGCGCTCACAG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAACCATCACAAACTCAGCCGCGGACACTGTTCCTCAGACTCCCT
CAGTAA

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 12306.16 Da
• Isoelectric Point: 10.2819

>AT239285 WP_245052879.1 NZ_CP094149:614919-615230 [Helicobacter pylori]
MPNTTAKKDYTRYSEKQLFNFLNSIKTKQKRALEKLKEIQAQKQRIKKALQFKALHLTENGYTIEEEREILARAKDTKNH
LCFKSVEDFKKHCENLRFKNADD

Nucleotide

• Length: 312 bp

>AT239285 NZ_LR890665:206423-206689 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Structures

Toxin

• AlphaFold DB: T0EUM7