Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 17730..18939 Replicon chromosome
Accession NZ_CP094149
Organism Helicobacter pylori strain Hpfe023

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag MPF84_RS00080 Protein ID WP_245085773.1
Coordinates 18157..18939 (+) Length 261 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag MPF84_RS00075 Protein ID WP_075707466.1
Coordinates 17730..18167 (+) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPF84_RS00060 (MPF84_00060) 15317..15899 + 583 Protein_10 hypothetical protein -
MPF84_RS00065 (MPF84_00065) 15868..16806 + 939 WP_245085771.1 RNA-directed DNA polymerase -
MPF84_RS00070 (MPF84_00070) 16834..17487 + 654 WP_245085772.1 hypothetical protein -
MPF84_RS00075 (MPF84_00075) 17730..18167 + 438 WP_075707466.1 Panacea domain-containing protein Antitoxin
MPF84_RS00080 (MPF84_00080) 18157..18939 + 783 WP_245085773.1 hypothetical protein Toxin
MPF84_RS00085 (MPF84_00085) 19166..20353 - 1188 WP_245085774.1 transcription termination factor NusA -
MPF84_RS00090 (MPF84_00090) 20441..21601 - 1161 WP_245085775.1 aminotransferase class V-fold PLP-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(24-119)


Sequences

Toxin        


Download         Length: 261 a.a.        Molecular weight: 30687.90 Da        Isoelectric Point: 9.5823

>T239284 WP_245085773.1 NZ_CP094149:18157-18939 [Helicobacter pylori]
METKEEDKDKKLEKIIVLLCEEGDLSSQKDQIIKDLKEIYKGEYKHKYSKITTIILNSTRDKEQAFMMLTQNIKTLKEIQ
DNKEVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKNVSIKLEDELNKNYKKLSEELNKQQTQYITILGIFASIVLTFV
GGLAFSTSVLSNIDKANAYRLVFVMAFIALFFGNILYRLFSFLSKISLSEEKKDKQENFFKKPIFWFNLMVIILFVIGFV
GERIDRQYKAHISKDFKRPR

Download         Length: 783 bp

>T239284 NZ_LR890659:c66387-66076 [Serratia marcescens]
ATGCACATTGTATCGAGAGCACCTTTCGATACAGCCACCAGGCAATTCCCCAATCAGGCAGCGGCACTAGACGACGTATA
CCGGACTTTGAAGAGAGAGAACTACACTTCACCGGACGAAATGAAAAAACGATTTGCCTCGCTGGACAGAATGAAATATC
GGGAGAAGTGGTGGGTGATCGATGTTGGCGGTGGGAATTTAAGGGTGATGTTTTTTGCTGATTTTGAACGTGGGAAAATC
TTTATAAAGCACATAACCACACACGCCGAATACGACAAGCTGACAGATTTTTACCGGAGAACTAAAGAATGA

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 17274.40 Da        Isoelectric Point: 6.1226

>AT239284 WP_075707466.1 NZ_CP094149:17730-18167 [Helicobacter pylori]
MVNTLELAKYILKHSNKELSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWKYGPVAREVYYEYRNYGANSIDKPKEETL
SQNLREDELETINCSIKKCNEKSYWDLVKESHKEDGAWHKSFREDRKEIISKDLIKQEAKQANGN

Download         Length: 438 bp

>AT239284 NZ_LR890659:c66079-65660 [Serratia marcescens]
ATGATGTACACCGATGCTATCCAGGCGGCAAACAGCCTGGTTAGCATTGTCCCCCTCCTGGGGGGCAATGCCTCTCGCAA
GGACTATGAAGACGCGCTGACGCTGGTTGAATACCTGGTTGAACACGAGCCAGATCATCCGCTGGTGGACATGCTGGTTG
CGAAAATTGCCCAGTATGAAGATGAGGCGGAAGAGTTCGCAGAGTTCAACGACCGTATTGCAGCGTTACCAAGTGGCGTG
GCCCTGCTGCGTGTCCTGATGGACCAGCACAAACTGACTCAGAGTGATTTTGAGGAAGAGATTGGTAAGAAATCGCTGGT
GAGCCGCATCCTTAACGGGACTCGCTCACTAACACTAGATCACATGAAAGCACTTGCGCGGCGCTTCAACATTCCGCCCA
GCTCATTCATGGACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References