Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 605988..606612 Replicon chromosome
Accession NZ_CP094148
Organism Helicobacter pylori strain Hpfe024

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MPG61_RS02935 Protein ID WP_231171737.1
Coordinates 606346..606612 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MPG61_RS02930 Protein ID WP_245020704.1
Coordinates 605988..606359 (+) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPG61_RS02900 (MPG61_02900) 601048..601278 + 231 WP_180444115.1 HypC/HybG/HupF family hydrogenase formation chaperone -
MPG61_RS02905 (MPG61_02905) 601306..602418 + 1113 WP_245020701.1 hydrogenase formation protein HypD -
MPG61_RS02910 (MPG61_02910) 602369..602890 - 522 WP_245020702.1 hypothetical protein -
MPG61_RS02925 (MPG61_02925) 603389..605617 + 2229 WP_245020703.1 Hop family adhesin BabA -
MPG61_RS02930 (MPG61_02930) 605988..606359 + 372 WP_245020704.1 hypothetical protein Antitoxin
MPG61_RS02935 (MPG61_02935) 606346..606612 + 267 WP_231171737.1 type II toxin-antitoxin system YafQ family toxin Toxin
MPG61_RS02940 (MPG61_02940) 606719..607243 - 525 WP_058338129.1 acyl-CoA thioesterase -
MPG61_RS02945 (MPG61_02945) 607383..608225 + 843 WP_245020705.1 SDR family oxidoreductase -
MPG61_RS02950 (MPG61_02950) 608218..609198 + 981 WP_000921482.1 iron ABC transporter permease -
MPG61_RS02955 (MPG61_02955) 609198..609965 + 768 WP_017282092.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10380.36 Da        Isoelectric Point: 10.0434

>T239283 WP_231171737.1 NZ_CP094148:606346-606612 [Helicobacter pylori]
MLKIKHHILYKKDFKKLIKNGFDDSVLNEVILTLRKKEPLDPQFKDHALKGNWKPFRECHIKADILLVYLVKGDELILVR
LGSHSELF

Download         Length: 267 bp

>T239283 NZ_LR890659:c38018-37536 [Serratia marcescens]
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGAAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCTACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGTGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGCGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 14357.24 Da        Isoelectric Point: 5.3605

>AT239283 WP_245020704.1 NZ_CP094148:605988-606359 [Helicobacter pylori]
MPNSPTKKDYTRYSEKQLFNLINQLEQKIKKMQNDRDSFKEKMAKELEKRDQNFKDKIDALNGLLQKISQAFDDKRDCCL
GCKIPNLETQQAMRDALNGENLETIEDLSAWANEVKKEVNAEN

Download         Length: 372 bp

>AT239283 NZ_LR890659:c38272-38006 [Serratia marcescens]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTAGAGATTGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCGCCAGTCGAGGATGATTCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References