Detailed information of TA system TA239282

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 592963..593533
• Replicon: chromosome
• Accession: NZ_CP094147
• Organism: Helicobacter pylori strain Hpfe027

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MPG27_RS02865
• Protein ID: WP_057112889.1
• Coordinates: 593261..593533 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: X2IKC6
• Locus tag: MPG27_RS02860
• Protein ID: WP_001133858.1
• Coordinates: 592963..593274 (+)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPG27_RS02830 (MPG27_02830)	588341..588913	-	573	WP_245043337.1	helicase DnaB modulator	-
MPG27_RS02845 (MPG27_02845)	589360..591591	+	2232	WP_245043115.1	Hop family adhesin BabA	-
MPG27_RS02850 (MPG27_02850)	592137..592529	+	393	WP_245043117.1	hypothetical protein	-
MPG27_RS02855 (MPG27_02855)	592510..592794	+	285	WP_000271050.1	endoribonuclease VapD	-
MPG27_RS02860 (MPG27_02860)	592963..593274	+	312	WP_001133858.1	type II toxin-antitoxin system antitoxin	Antitoxin
MPG27_RS02865 (MPG27_02865)	593261..593533	+	273	WP_057112889.1	type II toxin-antitoxin system YafQ family toxin	Toxin
MPG27_RS02870 (MPG27_02870)	593639..594163	-	525	WP_001135602.1	acyl-CoA thioesterase	-
MPG27_RS02875 (MPG27_02875)	594303..595145	+	843	WP_245043119.1	SDR family oxidoreductase	-
MPG27_RS02880 (MPG27_02880)	595138..596118	+	981	WP_000921438.1	iron ABC transporter permease	-
MPG27_RS02885 (MPG27_02885)	596118..596885	+	768	WP_245043121.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10656.66 Da
• Isoelectric Point: 9.7265

>T239282 WP_057112889.1 NZ_CP094147:593261-593533 [Helicobacter pylori]
MLMIETNKKFDKDLKILVKNGFDLKLLYKVVENLAKEQPLDPKYKDHPLKGTLKDFRECHLKPDLLLVYQIKKQENTLFL
VRLGSHSELF

Nucleotide

• Length: 273 bp

>T239282 NZ_LR890658:c14266-13916 [Serratia marcescens]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 12290.11 Da
• Isoelectric Point: 10.1678

>AT239282 WP_001133858.1 NZ_CP094147:592963-593274 [Helicobacter pylori]
MPNSPTKKDYTQYSEKQLFNFLNSIKTKQKRALEKLKEIQAQKQRIKKALQFKALHLTENGYTIEEEREILARAKDTKNH
LCFKSVEDFKKHCENLRFKNADD

Nucleotide

• Length: 312 bp

>AT239282 NZ_LR890658:c13911-13609 [Serratia marcescens]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA

Structures

Antitoxin

• AlphaFold DB: X2IKC6