Detailed information of TA system TA239281

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): VapD-relB/-
• Location: 592137..592794
• Replicon: chromosome
• Accession: NZ_CP094147
• Organism: Helicobacter pylori strain Hpfe027

Toxin (Protein)

• Gene name: VapD
• Uniprot ID: T5D7N9
• Locus tag: MPG27_RS02855
• Protein ID: WP_000271050.1
• Coordinates: 592510..592794 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MPG27_RS02850
• Protein ID: WP_245043117.1
• Coordinates: 592137..592529 (+)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPG27_RS02825 (MPG27_02825)	587278..588390	+	1113	WP_245043102.1	hydrogenase formation protein HypD	-
MPG27_RS02830 (MPG27_02830)	588341..588913	-	573	WP_245043337.1	helicase DnaB modulator	-
MPG27_RS02845 (MPG27_02845)	589360..591591	+	2232	WP_245043115.1	Hop family adhesin BabA	-
MPG27_RS02850 (MPG27_02850)	592137..592529	+	393	WP_245043117.1	hypothetical protein	Antitoxin
MPG27_RS02855 (MPG27_02855)	592510..592794	+	285	WP_000271050.1	endoribonuclease VapD	Toxin
MPG27_RS02860 (MPG27_02860)	592963..593274	+	312	WP_001133858.1	type II toxin-antitoxin system antitoxin	-
MPG27_RS02865 (MPG27_02865)	593261..593533	+	273	WP_057112889.1	type II toxin-antitoxin system YafQ family toxin	-
MPG27_RS02870 (MPG27_02870)	593639..594163	-	525	WP_001135602.1	acyl-CoA thioesterase	-
MPG27_RS02875 (MPG27_02875)	594303..595145	+	843	WP_245043119.1	SDR family oxidoreductase	-
MPG27_RS02880 (MPG27_02880)	595138..596118	+	981	WP_000921438.1	iron ABC transporter permease	-
MPG27_RS02885 (MPG27_02885)	596118..596885	+	768	WP_245043121.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Virulence-associated protein D / CRISPR associated protein Cas2 (1-87)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11188.74 Da
• Isoelectric Point: 4.8896

>T239281 WP_000271050.1 NZ_CP094147:592510-592794 [Helicobacter pylori]
MYALAFDLKIEILKKEYGEPYNKAYDDLRQELELLGFEWTQGSVYVNYSKENTLAQVYKAINKLSQIEWFKKSVRDIRAF
KVEDFSDFTEIVKS

Nucleotide

• Length: 285 bp

>T239281 NZ_LR890657:c4487193-4486771 [Serratia marcescens]
GTGGCCCAGTGGCGATGTGATATCCGCATTTCCTGGCGCACTCAGCTGTTTTCCCTGTTGACCCACGGCGTTCTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAAGGCTTTGGTCCGCTCTGGCTGGTGCTGCTGACGCTGGTGGTGTTTCAGTGCA
TTCGCAGCCAGAAGCGCATCGCCGCGGTGCAGGGCGAGCTGCGGCTGTTGGCGGACCGGCGCTTCAGCTGGCACGGCCGC
GAGTGGCGGCTGGCGAAAAAACCGTGGATGCCGGGTTACGGCATGCTGCTGACGCTGCAGCCGACGGAGGGCAAAAAGCG
CCGCCGGCTGTGGCTGGCTTCCGACTGCATGAGCAAAGAGGAGTGGCGCCACCTGCGGCAGCTGTTGCTGTATCCTCCGA
CGGGTGACGGCGAACCAGAGTGA

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 15228.33 Da
• Isoelectric Point: 8.7032

>AT239281 WP_245043117.1 NZ_CP094147:592137-592529 [Helicobacter pylori]
MPNSPTKKDYTQYSEKQLFNLINQLEQKIKKMQNDRASFKEKMAKELDKRDQNFKDKIDALNELLQKISQAFDDKRDCCL
RHKIPNLETQQAMRDALNGVNLTQIDSLDDLTNELKRENGKGFKNVCFSV

Nucleotide

• Length: 393 bp

>AT239281 NZ_LR890657:c4487440-4487174 [Serratia marcescens]
ATGGATATTAACAACAAAGCACGTATTCACTGGGCTTGCCGCCGTGGCATGCGCGAGCTGGACATCTCCATCATGCCGTT
CTTCGAATACGAATACGACAGCCTGAATGACGCGGACAAGGCGTTGTTCATCCGCCTGCTGGAGTGCGACGATCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCGCCGCAGGACAGCGAGCTGCAGAGAATGGTGACCCTGATCCAAACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA

Structures

Toxin

• PDB: 3UI3