Detailed information of TA system TA239280

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 17930..19121
• Replicon: chromosome
• Accession: NZ_CP094145
• Organism: Helicobacter pylori strain Hpfe028

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: MPG51_RS00075
• Protein ID: WP_245034194.1
• Coordinates: 18357..19121 (+)
• Length: 255 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: MPG51_RS00070
• Protein ID: WP_245034192.1
• Coordinates: 17930..18367 (+)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPG51_RS00060 (MPG51_00060)	15522..16073	+	552	WP_245034190.1	hypothetical protein	-
MPG51_RS00065 (MPG51_00065)	16084..17706	+	1623	WP_245035065.1	reverse transcriptase domain-containing protein	-
MPG51_RS00070 (MPG51_00070)	17930..18367	+	438	WP_245034192.1	Panacea domain-containing protein	Antitoxin
MPG51_RS00075 (MPG51_00075)	18357..19121	+	765	WP_245034194.1	hypothetical protein	Toxin
MPG51_RS00080 (MPG51_00080)	19350..20537	-	1188	WP_245034196.1	transcription termination factor NusA	-
MPG51_RS00085 (MPG51_00085)	20625..21785	-	1161	WP_245034198.1	aminotransferase class V-fold PLP-dependent enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (24-119)

Sequences

Toxin

Protein

• Length: 255 a.a.
• Molecular weight: 29767.81 Da
• Isoelectric Point: 7.7546

>T239280 WP_245034194.1 NZ_CP094145:18357-19121 [Helicobacter pylori]
MEIKEENKDKKLEKIIVLLCEEGDLSSQKDQIIKDLKEIYEGEYKHKYSKITTTILNSTRDKEQAFMTLTQNIKTLKEIQ
DNKEVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKDVSIKLEDELNKNYKKLSEELNKQQTQYITILGIFASIVLTFV
GGLAFSTSVLSNIDKANAYRLVFVMAFIALFFGNILCLLFSFLSKISLSEEKKDKQENFFKKFIFWFNLMVTILFVIGFV
GELHIIQRLASKYF

Nucleotide

• Length: 765 bp

>T239280 NZ_CP094145:18357-19121 [Helicobacter pylori]
ATGGAAATTAAAGAAGAGAATAAAGATAAAAAGCTAGAAAAAATTATTGTATTGTTGTGCGAAGAGGGGGATTTGTCTAG
TCAAAAAGATCAAATCATCAAAGATCTCAAAGAAATCTATGAAGGAGAATACAAGCATAAATACTCAAAAATCACAACTA
CTATTTTAAATTCTACAAGGGATAAAGAGCAAGCCTTTATGACGCTCACACAAAATATAAAGACGCTCAAAGAGATTCAA
GATAATAAAGAAGTTGAAAGCATTAAACCAAAACTAGAAAAGCTTTATGATCACATGAATTTAGAGTGTATCAGACTGCA
AGATTTTGATGAGAAAATGAGTAGAGTTAAAGATGTTTCTATAAAGTTAGAAGATGAACTAAATAAAAACTATAAAAAAT
TAAGCGAAGAATTGAATAAGCAACAAACACAATACATAACAATTCTAGGTATTTTTGCCTCTATTGTTTTAACATTTGTT
GGGGGATTGGCGTTTTCCACTTCTGTTTTATCAAATATTGACAAAGCGAACGCCTATCGTTTGGTTTTTGTTATGGCTTT
TATAGCTTTATTTTTTGGGAATATTTTGTGTTTGCTTTTTTCTTTTTTATCAAAAATATCCTTATCAGAAGAGAAAAAAG
ATAAACAAGAAAATTTTTTCAAAAAATTTATTTTTTGGTTTAATCTAATGGTTACAATTCTATTTGTGATTGGTTTTGTG
GGAGAATTGCATATAATACAAAGATTAGCTTCTAAATATTTTTAA

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 17255.38 Da
• Isoelectric Point: 6.4976

>AT239280 WP_245034192.1 NZ_CP094145:17930-18367 [Helicobacter pylori]
MVNALELAKYILKHSNKELSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWKYGPVAREVYYEYRNYGANSIDKPKEETL
SQNLRKDELETINRSIEKCNEKSYWDLVKESHKEDGAWHKSFKEDRKEVISKDLIKQEAKQANGN

Nucleotide

• Length: 438 bp

>AT239280 NZ_CP094145:17930-18367 [Helicobacter pylori]
ATGGTCAATGCTTTGGAATTAGCAAAATATATTCTTAAGCATTCCAACAAAGAATTGAGCAACTTAGAATTGCAAAAAAC
TTTGTATTTCACAGAGCTTGACTATATTAAAAAGTTTGACAAACACCTAGTTTCTGATGATTTTGAAGCTTGGAAATACG
GACCTGTTGCAAGGGAAGTGTATTATGAATATCGCAATTATGGTGCCAATTCCATTGACAAACCCAAAGAAGAAACGCTC
TCGCAAAATCTTAGAAAAGATGAACTTGAAACCATCAATCGCTCCATAGAAAAATGCAACGAAAAATCCTATTGGGATTT
AGTGAAAGAGAGTCATAAAGAAGATGGTGCTTGGCATAAAAGCTTCAAAGAAGATAGAAAAGAAGTCATTAGCAAAGATT
TGATCAAACAAGAAGCAAAACAAGCGAATGGAAATTAA